Activation of oxidative stress response in cancer generates a druggable dependency on exogenous non-essential amino acids

por LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales
Publicado en Cell Metab (2019)

Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

por Lignitto, Luca, LeBoeuf, Sarah E., Homer, Harrison, Jiang, Shaowen, Askenazi, Manor, Karakousi, Triantafyllia R., Pass, Harvey I., Bhutkar, Arjun J., Tsirigos, Aristotelis, Ueberheide, Beatrix, Sayin, Volkan I., Papagiannakopoulos, Thales, Pagano, Michele
Publicado en Cell (2019)

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase Epsilon

por Sviderskiy, Vladislav O., Blumenberg, Lili, Gorodetsky, Elizabeth, Karakousi, Triantafyllia R., Hirsh, Nicole, Alvarez, Samantha W., Terzi, Erdem M., Kaparos, Efiyenia, Whiten, Gabrielle C., Ssebyala, Shakirah, Tonzi, Peter, Mir, Hannan, Neel, Benjamin G., Huang, Tony T., Adams, Sylvia, Ruggles, Kelly V., Possemato, Richard
Publicado en Mol Cell (2020)

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

por Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales
Publicado en eLife (2017)

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis

por Romero, Rodrigo, Sayin, Volkan I., Davidson, Shawn M., Bauer, Matthew R., Singh, Simranjit X., LeBoeuf, Sarah E., Karakousi, Triantafyllia R., Ellis, Donald C., Bhutkar, Arjun, Sanchez-Rivera, Francisco J., Subbaraj, Lakshmipriya, Martinez, Britney, Bronson, Roderick T., Prigge, Justin R., Schmidt, Edward E., Thomas, Craig J., Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T., Moreira, Andre L., Rudin, Charles M., Pass, Harvey I., Vander Heiden, Matthew G., Jacks, Tyler, Papagiannakopoulos, Thales
Publicado en Nat Med (2017)