Activation of oxidative stress response in cancer generates a druggable dependency on exogenous non-essential amino acids

by LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales
Published in Cell Metab (2019)

Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

by Lignitto, Luca, LeBoeuf, Sarah E., Homer, Harrison, Jiang, Shaowen, Askenazi, Manor, Karakousi, Triantafyllia R., Pass, Harvey I., Bhutkar, Arjun J., Tsirigos, Aristotelis, Ueberheide, Beatrix, Sayin, Volkan I., Papagiannakopoulos, Thales, Pagano, Michele
Published in Cell (2019)

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase Epsilon

by Sviderskiy, Vladislav O., Blumenberg, Lili, Gorodetsky, Elizabeth, Karakousi, Triantafyllia R., Hirsh, Nicole, Alvarez, Samantha W., Terzi, Erdem M., Kaparos, Efiyenia, Whiten, Gabrielle C., Ssebyala, Shakirah, Tonzi, Peter, Mir, Hannan, Neel, Benjamin G., Huang, Tony T., Adams, Sylvia, Ruggles, Kelly V., Possemato, Richard
Published in Mol Cell (2020)

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

by Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales
Published in eLife (2017)

Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis

by Romero, Rodrigo, Sayin, Volkan I., Davidson, Shawn M., Bauer, Matthew R., Singh, Simranjit X., LeBoeuf, Sarah E., Karakousi, Triantafyllia R., Ellis, Donald C., Bhutkar, Arjun, Sanchez-Rivera, Francisco J., Subbaraj, Lakshmipriya, Martinez, Britney, Bronson, Roderick T., Prigge, Justin R., Schmidt, Edward E., Thomas, Craig J., Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T., Moreira, Andre L., Rudin, Charles M., Pass, Harvey I., Vander Heiden, Matthew G., Jacks, Tyler, Papagiannakopoulos, Thales
Published in Nat Med (2017)