New Approaches in Detection and Treatment of Familial Hypercholesterolemia

Por Hartgers, Merel L., Ray, Kausik K., Hovingh, G. Kees
Publicado no Curr Cardiol Rep (2015)

Retrospective analysis of cohort database: Phenotypic variability in a large dataset of patients confirmed to have homozygous familial hypercholesterolemia

Por Raal, Frederick J., Sjouke, Barbara, Hovingh, G. Kees, Isaac, Barton F.
Publicado no Data Brief (2016)

Prevention of cardiovascular disease in patients with familial hypercholesterolaemia: The role of PCSK9 inhibitors

Por Pećin, Ivan, Hartgers, Merel L, Hovingh, G Kees, Dent, Ricardo, Reiner, Željko
Publicado no Eur J Prev Cardiol (2017)

The PCSK9 decade: Thematic Review Series: New Lipid and Lipoprotein Targets for the Treatment of Cardiometabolic Diseases

Por Lambert, Gilles, Sjouke, Barbara, Choque, Benjamin, Kastelein, John J. P., Hovingh, G. Kees
Publicado em 2012

High-Density Lipoprotein (HDL) Particle Subpopulations in Heterozygous Cholesteryl Ester Transfer Protein (CETP) Deficiency: Maintenance of Antioxidative Activity

Por Chantepie, Sandrine, Bochem, Andrea E., Chapman, M. John, Hovingh, G. Kees, Kontush, Anatol
Publicado em 2012

Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection

Por Herman, Daniel S, Hovingh, G Kees, Iartchouk, Oleg, Rehm, Heidi L, Kucherlapati, Raju, Seidman, J G, Seidman, Christine E
Publicado em 2009

Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein(a) levels and genotype: The EPIC-Norfolk prospective population study

Por Perrot, Nicolas, Verbeek, Rutger, Sandhu, Manjinder, Boekholdt, S. Matthijs, Hovingh, G. Kees, Wareham, Nicholas J., Khaw, Kay-Tee, Arsenault, Benoit J.
Publicado no Atherosclerosis (2017)

Effects of Supra-Physiological Levothyroxine Dosages on Liver Parameters, Lipids and Lipoproteins in Healthy Volunteers: A Randomized Controlled Crossover Study

Por Sjouke, Barbara, Elbers, Laura P. B., van Zaane, Bregje, Kastelein, John J. P., Hovingh, G. Kees, Gerdes, Victor E. A.
Publicado no Sci Rep (2017)

Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study

Por Kastelein, John J.P., Nissen, Steven E., Rader, Daniel J., Hovingh, G. Kees, Wang, Ming-Dauh, Shen, Tong, Krueger, Kathryn A.
Publicado no Eur Heart J (2016)

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study(1)

Por Verbeek, Rutger, Boekholdt, S. Matthijs, Stoekenbroek, Robert M., Hovingh, G. Kees, Witztum, Joseph L., Wareham, Nicholas J., Sandhu, Manjinder S., Khaw, Kay-Tee, Tsimikas, Sotirios
Publicado no J Lipid Res (2016)

eNOS Activation by HDL Is Impaired in Genetic CETP Deficiency

Por Gomaraschi, Monica, Ossoli, Alice, Pozzi, Silvia, Nilsson, Peter, Cefalù, Angelo B., Averna, Maurizio, Kuivenhoven, Jan Albert, Hovingh, G. Kees, Veglia, Fabrizio, Franceschini, Guido, Calabresi, Laura
Publicado em 2014

Adrenal Function in Females with Low Plasma HDL-C Due to Mutations in ABCA1 and LCAT

Por Bochem, Andrea E., Holleboom, Adriaan G., Romijn, Johannes A., Hoekstra, Menno, Dallinga, Geesje M., Motazacker, Mahdi M., Hovingh, G. Kees, Kuivenhoven, Jan A., Stroes, Erik S. G.
Publicado em 2014

High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C

Por Bochem, Andrea E., Holleboom, Adriaan G., Romijn, Johannes A., Hoekstra, Menno, Dallinga-Thie, Geesje M., Motazacker, Mahdi M., Hovingh, G. Kees, Kuivenhoven, Jan A., Stroes, Erik S. G.
Publicado em 2013

Lipoprotein (a) and risk of coronary, cerebrovascular and peripheral artery disease; the EPIC-Norfolk prospective population study

Por Gurdasani, Deepti, Sjouke, Barbara, Tsimikas, Sotirios, Hovingh, G. Kees, Luben, Robert N., Wainwright, Nicholas W. J., Pomilla, Cristina, Wareham, Nicholas J., Khaw, Kay-Tee, Boekholdt, S. Matthijs, Sandhu, Manjinder S.
Publicado em 2012

Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol

Por Tietjen, Ian, Hovingh, G. Kees, Singaraja, Roshni R., Radomski, Chris, Barhdadi, Amina, McEwen, Jason, Chan, Elden, Mattice, Maryanne, Legendre, Annick, Franchini, Patrick L., Dubé, Marie-Pierre, Kastelein, John J. P., Hayden, Michael R.
Publicado em 2012

Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies

Por Banach, Maciej, Serban, Corina, Sahebkar, Amirhossein, Mikhailidis, Dimitri P., Ursoniu, Sorin, Ray, Kausik K., Rysz, Jacek, Toth, Peter P., Muntner, Paul, Mosteoru, Svetlana, García-García, Hector M., Hovingh, G. Kees, Kastelein, John JP, Serruys, Patrick W.
Publicado no BMC Med (2015)

GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia

Por Hu, Xuchen, Dallinga-Thie, Geesje M., Hovingh, G. Kees, Chang, Sandy Y., Sandoval, Norma P., Dang, Tiffany Ly P., Fukamachi, Isamu, Miyashita, Kazuya, Nakajima, Katsuyuki, Murakami, Masami, Fong, Loren G., Ploug, Michael, Young, Stephen G., Beigneux, Anne P.
Publicado no J Clin Lipidol (2017)

Lipid Oxidation in Carriers of Lecithin:Cholesterol Acyltransferase Gene Mutations

Por Holleboom, Adriaan G., Daniil, Georgios, Fu, Xiaoming, Zhang, Renliang, Hovingh, G. Kees, Schimmel, Alinda W., Kastelein, John J.P., Stroes, Erik S.G., Witztum, Joseph L., Hutten, Barbara A., Tsimikas, Sotirios, Hazen, Stanley L., Chroni, Angeliki, Kuivenhoven, Jan Albert
Publicado em 2012

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1

Por Holleboom, Adriaan G., Jakulj, Lily, Franssen, Remco, Decaris, Julie, Vergeer, Menno, Koetsveld, Joris, Luchoomun, Jayraz, Glass, Alexander, Hellerstein, Marc K., Kastelein, John J. P., Hovingh, G. Kees, Kuivenhoven, Jan Albert, Groen, Albert K., Turner, Scott M., Stroes, Erik S. G.
Publicado em 2013

Common genetic variants do not associate with CAD in familial hypercholesterolemia

Por van Iperen, Erik P A, Sivapalaratnam, Suthesh, Boekholdt, S Matthijs, Hovingh, G Kees, Maiwald, Stephanie, Tanck, Michael W, Soranzo, Nicole, Stephens, Jonathan C, Sambrook, Jennifer G, Levi, Marcel, Ouwehand, Willem H, Kastelein, John JP, Trip, Mieke D, Zwinderman, Aeilko H
Publicado em 2014