The Efficacy of Antigen Processing Is Critical for Protection against Cytomegalovirus Disease in the Presence of Viral Immune Evasion Proteins

Por Holtappels, Rafaela, Thomas, Doris, Reddehase, Matthias J.
Publicado em 2009

Two Antigenic Peptides from Genes m123 and m164 of Murine Cytomegalovirus Quantitatively Dominate CD8 T-Cell Memory in the H-2(d) Haplotype

Por Holtappels, Rafaela, Thomas, Doris, Podlech, Jürgen, Reddehase, Matthias J.
Publicado em 2002

Preemptive CD8 T-Cell Immunotherapy of Acute Cytomegalovirus Infection Prevents Lethal Disease, Limits the Burden of Latent Viral Genomes, and Reduces the Risk of Virus Recurrence

Por Steffens, Hans-Peter, Kurz, Sabine, Holtappels, Rafaela, Reddehase, Matthias J.
Publicado em 1998

Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62L(lo) Memory-Effector Cell Pool during Latent Murine Cytomegalovirus Infection of the L...

Por Holtappels, Rafaela, Pahl-Seibert, Marcus-Folker, Thomas, Doris, Reddehase, Matthias J.
Publicado em 2000

Control of Murine Cytomegalovirus Infection by γδ T Cells

Por Sell, Sabrina, Dietz, Monika, Schneider, Andrea, Holtappels, Rafaela, Mach, Michael, Winkler, Thomas H.
Publicado no PLoS Pathog (2015)

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance

Por Holtappels, Rafaela, Lemmermann, Niels A. W., Podlech, Jürgen, Ebert, Stefan, Reddehase, Matthias J.
Publicado no Front Immunol (2016)

Control of Murine Cytomegalovirus in the Lungs: Relative but Not Absolute Immunodominance of the Immediate-Early 1 Nonapeptide during the Antiviral Cytolytic T-Lymphocyte Respons...

Por Holtappels, Rafaela, Podlech, Jürgen, Geginat, Gernot, Steffens, Hans-Peter, Thomas, Doris, Reddehase, Matthias J.
Publicado em 1998

Murine Model of Interstitial Cytomegalovirus Pneumonia in Syngeneic Bone Marrow Transplantation: Persistence of Protective Pulmonary CD8-T-Cell Infiltrates after Clearance of Acut...

Por Podlech, Jürgen, Holtappels, Rafaela, Pahl-Seibert, Marcus-Folker, Steffens, Hans-Peter, Reddehase, Matthias J.
Publicado em 2000

The Putative Natural Killer Decoy Early Gene m04 (gp34) of Murine Cytomegalovirus Encodes an Antigenic Peptide Recognized by Protective Antiviral CD8 T Cells

Por Holtappels, Rafaela, Thomas, Doris, Podlech, Jürgen, Geginat, Gernot, Steffens, Hans-Peter, Reddehase, Matthias J.
Publicado em 2000

Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus

Por Hengel, Hartmut, Reusch, Uwe, Geginat, Gernot, Holtappels, Rafaela, Ruppert, Thomas, Hellebrand, Eva, Koszinowski, Ulrich H.
Publicado em 2000

In Vivo Replication of Recombinant Murine Cytomegalovirus Driven by the Paralogous Major Immediate-Early Promoter-Enhancer of Human Cytomegalovirus

Por Grzimek, Natascha K. A., Podlech, Jürgen, Steffens, Hans-Peter, Holtappels, Rafaela, Schmalz, Susanne, Reddehase, Matthias J.
Publicado em 1999

Processing and Presentation of Murine Cytomegalovirus pORFm164-Derived Peptide in Fibroblasts in the Face of All Viral Immunosubversive Early Gene Functions

Por Holtappels, Rafaela, Grzimek, Natascha K. A., Simon, Christian O., Thomas, Doris, Dreis, Doris, Reddehase, Matthias J.
Publicado em 2002

Noncanonical Expression of a Murine Cytomegalovirus Early Protein CD8 T-Cell Epitope as an Immediate Early Epitope Based on Transcription from an Upstream Gene

Por Fink, Annette, Büttner, Julia K., Thomas, Doris, Holtappels, Rafaela, Reddehase, Matthias J., Lemmermann, Niels A. W.
Publicado em 2014

Experimental Preemptive Immunotherapy of Murine Cytomegalovirus Disease with CD8 T-Cell Lines Specific for ppM83 and pM84, the Two Homologs of Human Cytomegalovirus Tegument Prot...

Por Holtappels, Rafaela, Podlech, Jürgen, Grzimek, Natascha K. A., Thomas, Doris, Pahl-Seibert, Marcus-Folker, Reddehase, Matthias J.
Publicado em 2001

Highly Protective In Vivo Function of Cytomegalovirus IE1 Epitope-Specific Memory CD8 T Cells Purified by T-Cell Receptor-Based Cell Sorting

Por Pahl-Seibert, Marcus-Folker, Juelch, Markus, Podlech, Jürgen, Thomas, Doris, Deegen, Petra, Reddehase, Matthias J., Holtappels, Rafaela
Publicado em 2005

Immune Evasion Proteins Enhance Cytomegalovirus Latency in the Lungs

Por Böhm, Verena, Seckert, Christof K., Simon, Christian O., Thomas, Doris, Renzaho, Angélique, Gendig, Dorothea, Holtappels, Rafaela, Reddehase, Matthias J.
Publicado em 2009

Control of Cytomegalovirus in Bone Marrow Transplantation Chimeras Lacking the Prevailing Antigen-Presenting Molecule in Recipient Tissues Rests Primarily on Recipient-Derived CD...

Por Alterio de Goss, Mariagabriela, Holtappels, Rafaela, Steffens, Hans-Peter, Podlech, Jürgen, Angele, Peter, Dreher, Liane, Thomas, Doris, Reddehase, Matthias J.
Publicado em 1998

Cytomegalovirus Misleads Its Host by Priming of CD8 T Cells Specific for an Epitope Not Presented in Infected Tissues

Por Holtappels, Rafaela, Podlech, Jürgen, Pahl-Seibert, Marcus-Folker, Jülch, Markus, Thomas, Doris, Simon, Christian O., Wagner, Markus, Reddehase, Matthias J.
Publicado em 2004

Cytomegalovirus Encodes a Positive Regulator of Antigen Presentation

Por Holtappels, Rafaela, Gillert-Marien, Dorothea, Thomas, Doris, Podlech, Jürgen, Deegen, Petra, Herter, Sylvia, Oehrlein-Karpi, Silke A., Strand, Dennis, Wagner, Markus, Reddehase, Matthias J.
Publicado em 2006

The Immune Evasion Paradox: Immunoevasins of Murine Cytomegalovirus Enhance Priming of CD8 T Cells by Preventing Negative Feedback Regulation

Por Böhm, Verena, Simon, Christian O., Podlech, Jürgen, Seckert, Christof K., Gendig, Dorothea, Deegen, Petra, Gillert-Marien, Dorothea, Lemmermann, Niels A. W., Holtappels, Rafaela, Reddehase, Matthias J.
Publicado em 2008