Neural organoids for disease phenotyping, drug screening and developmental biology studies

Por Hartley, Brigham J., Brennand, Kristen J.
Publicado no Neurochem Int (2016)

Dopaminergic differentiation of schizophrenia hiPSCs

Por Hartley, Brigham J., Tran, Ngoc, Ladran, Ian, Reggio, Kathryn, Brennand, Kristen J.
Publicado no Mol Psychiatry (2015)

Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells

Por Hartley, Brigham J., Fabb, Stewart A., Finnin, Ben A.L., Haynes, John M., Pouton, Colin W.
Publicado no J Vis Exp (2014)

Human pluripotent stem cell derived midbrain PITX3(eGFP/w) neurons: a versatile tool for pharmacological screening and neurodegenerative modeling

Por Watmuff, Bradley, Hartley, Brigham J., Hunt, Cameron P. J., Fabb, Stewart A., Pouton, Colin W., Haynes, John M.
Publicado no Front Cell Neurosci (2015)

Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells

Por Ho, Seok-Man, Hartley, Brigham J., Julia, TCW, Beaumont, Michael, Stafford, Khalifa, Slesinger, Paul A., Brennand, Kristen J.
Publicado no Methods (2015)

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

Por Hoffman, Gabriel E., Hartley, Brigham J., Flaherty, Erin, Ladran, Ian, Gochman, Peter, Ruderfer, Douglas M., Stahl, Eli A., Rapoport, Judith, Sklar, Pamela, Brennand, Kristen J.
Publicado no Nat Commun (2017)

Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes

Por Ho, Seok-Man, Hartley, Brigham J., Flaherty, Erin, Rajarajan, Prashanth, Abdelaal, Rawan, Obiorah, Ifeanyi, Barretto, Natalie, Muhammad, Hamza, Phatnani, Hemali P., Akbarian, Schahram, Brennand, Kristen J.
Publicado no Stem Cell Reports (2017)

In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain

Por Chatterton, Zac, Hartley, Brigham J., Seok, Man-Ho, Mendelev, Natalia, Chen, Sean, Milekic, Maria, Rosoklija, Gorazd, Stankov, Aleksandar, Trencevsja-Ivanovska, Iskra, Brennand, Kristen, Ge, Yongchao, Dwork, Andrew J., Haghighi, Fatemeh
Publicado no Epigenetics Chromatin (2017)

High Content Screening in hESC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain

Por Zhou, Ting, Tan, Lei, Cederquist, Gustav Y., Fan, Yujie, Hartley, Brigham J., Mukherjee, Suranjit, Tomishima, Mark, Brennand, Kristen J., Zhang, Qisheng, Schwartz, Robert E., Evans, Todd, Studer, Lorenz, Chen, Shuibing
Publicado no Cell Stem Cell (2017)

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

Por TCW, Julia, Wang, Minghui, Pimenova, Anna A., Bowles, Kathryn R., Hartley, Brigham J., Lacin, Emre, Machlovi, Saima I., Abdelaal, Rawan, Karch, Celeste M., Phatnani, Hemali, Slesinger, Paul A., Zhang, Bin, Goate, Alison M., Brennand, Kristen J.
Publicado no Stem Cell Reports (2017)

Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells

Por Lee, Inkyu S, Carvalho, Claudia M B, Douvaras, Panagiotis, Ho, Seok-Man, Hartley, Brigham J, Zuccherato, Luciana W, Ladran, Ian G, Siegel, Arthur J, McCarthy, Shane, Malhotra, Dheeraj, Sebat, Jonathan, Rapoport, Judith, Fossati, Valentina, Lupski, James R, Levy, Deborah L, Brennand, Kristen J
Publicado no NPJ Schizophr (2015)

Dysregulation of miRNA-9 in a subset of schizophrenia patient-derived neural progenitor cells

Por Topol, Aaron, Zhu, Shijia, Hartley, Brigham J., English, Jane, Hauberg, Mads E., Readhead, Ben, Tran, Ngoc, Rittenhouse, Chelsea Ann, Simone, Anthony, Ruderfer, Douglas M., Johnson, Jessica, Hadas, Yoav, Gochman, Peter A., Wang, Ying-Chih, Shah, Hardik, Cagney, Gerard, Rapoport, Judith, Gage, Fred H., Dudley, Joel T., Sklar, Pamela, Mattheisen, Manuel, Cotter, David, Fang, Gang, Brennand, Kristen J.
Publicado no Cell Rep (2016)

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

Por Topol, Aaron, Zhu, Shijia, Hartley, Brigham J., English, Jane, Hauberg, Mads E., Tran, Ngoc, Rittenhouse, Chelsea Ann, Simone, Anthony, Ruderfer, Douglas M., Johnson, Jessica, Readhead, Ben, Hadas, Yoav, Gochman, Peter A., Wang, Ying-Chih, Shah, Hardik, Cagney, Gerard, Rapoport, Judith, Gage, Fred H., Dudley, Joel T., Sklar, Pamela, Mattheisen, Manuel, Cotter, David, Fang, Gang, Brennand, Kristen J.
Publicado no Cell Rep (2017)

Kmt1e regulates a large neuron-specific topological chromatin domain

Por Jiang, Yan, Loh, Yong-Hwee Eddie, Rajarajan, Prashanth, Hirayama, Teruyoshi, Liao, Will, Kassim, Bibi S., Javidfar, Behnam, Hartley, Brigham J, Kleofas, Lisa, Park, Royce B, Labonte, Benoit, Ho, Seok-Man, Chandrasekaran, Sandhya, Do, Catherine, Ramirez, Brianna R, Peter, Cyril J., Julia, TCW, Safaie, Brian M, Morishita, Hirofumi, Roussos, Panos, Nestler, Eric J, Schaefer, Anne, Tycko, Benjamin, Brennand, Kristen J, Yagi, Takeshi, Shen, Li, Akbarian, Schahram
Publicado no Nat Genet (2017)