High Content Screening in hESC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain

Zika virus (ZIKV) infects fetal and adult human brain, and is associated with serious neurological complications. To date, no therapeutic treatment is available to treat ZIKV infected patients. We performed a high content chemical screen using human embryonic stem cell derived cortical neuron progen...

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Publicado en:Cell Stem Cell
Main Authors: Zhou, Ting, Tan, Lei, Cederquist, Gustav Y., Fan, Yujie, Hartley, Brigham J., Mukherjee, Suranjit, Tomishima, Mark, Brennand, Kristen J., Zhang, Qisheng, Schwartz, Robert E., Evans, Todd, Studer, Lorenz, Chen, Shuibing
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553280/
https://ncbi.nlm.nih.gov/pubmed/28736217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.06.017
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