Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms

Por Hapgood, Janet P., Kaushic, Charu, Hel, Zdenek
Publicado no Endocr Rev (2018)

Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy

Por Hapgood, Janet P., Avenant, Chanel, Moliki, Johnson M.
Publicado no Pharmacol Ther (2016)

Medroxyprogesterone Acetate Differentially Regulates Interleukin (IL)-12 and IL-10 in a Human Ectocervical Epithelial Cell Line in a Glucocorticoid Receptor (GR)-dependent Manner

Por Louw-du Toit, Renate, Hapgood, Janet P., Africander, Donita
Publicado no J Biol Chem (2014)

Impact of Glucocorticoid Receptor Density on Ligand-Independent Dimerization, Cooperative Ligand-Binding and Basal Priming of Transactivation: A Cell Culture Model

Por Robertson, Steven, Rohwer, Johann M., Hapgood, Janet P., Louw, Ann
Publicado em 2013

Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects

Por Stanczyk, Frank Z., Hapgood, Janet P., Winer, Sharon, Mishell, Daniel R.
Publicado em 2013

Lipid Raft- and Protein Kinase C-mediated Synergism between Glucocorticoid- and Gonadotropin-releasing Hormone Signaling Results in Decreased Cell Proliferation

Por Wehmeyer, Lancelot, Du Toit, Andrea, Lang, Dirk M., Hapgood, Janet P.
Publicado em 2014

Comparing the androgenic and estrogenic properties of progestins used in contraception and hormone therapy

Por Louw-du Toit, Renate, Perkins, Meghan S., Hapgood, Janet P., Africander, Donita
Publicado no Biochem Biophys Res Commun (2017)

Is a lower-dose, subcutaneous contraceptive injectable containing depot medroxyprogesterone acetate likely to impact women’s risk of HIV?

Por Polis, Chelsea B., Achilles, Sharon L., Hel, Zdenek, Hapgood, Janet P.
Publicado no Contraception (2017)

Glucocorticoid-independent Repression of Tumor Necrosis Factor (TNF) α-stimulated Interleukin (IL)-6 Expression by the Glucocorticoid Receptor: A POTENTIAL MECHANISM FOR PROTECTION...

Por Verhoog, Nicolette J. D., Du Toit, Andrea, Avenant, Chanel, Hapgood, Janet P.
Publicado em 2011

The Progestin-Only Contraceptive Medroxyprogesterone Acetate, but Not Norethisterone Acetate, Enhances HIV-1 Vpr-Mediated Apoptosis in Human CD4(+) T Cells through the Glucocortico...

Por Tomasicchio, Michele, Avenant, Chanel, Du Toit, Andrea, Ray, Roslyn M., Hapgood, Janet P.
Publicado em 2013

Genomic and Nongenomic Cross Talk between the Gonadotropin-Releasing Hormone Receptor and Glucocorticoid Receptor Signaling Pathways

Por Kotitschke, Andrea, Sadie-Van Gijsen, Hanél, Avenant, Chanel, Fernandes, Sandra, Hapgood, Janet P.
Publicado no Mol Endocrinol (2009)

Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus)

Por Illing, Nicola, Troskie, Brigitte E., Nahorniak, Carol S., Hapgood, Janet P., Peter, Richard E., Millar, Robert P.
Publicado em 1999

The Injectable-Only Contraceptive Medroxyprogesterone Acetate, Unlike Norethisterone Acetate and Progesterone, Regulates Inflammatory Genes in Endocervical Cells via the Glucocorti...

Por Govender, Yashini, Avenant, Chanel, Verhoog, Nicolette J. D., Ray, Roslyn M., Grantham, Nicholas J., Africander, Donita, Hapgood, Janet P.
Publicado em 2014

Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line, via mechanisms involving the...

Por Maritz, Michelle F., Ray, Roslyn M., Bick, Alexis J., Tomasicchio, Michele, Woodland, John G., Govender, Yashini, Avenant, Chanel, Hapgood, Janet P.
Publicado no PLoS One (2018)