Glucocorticoid-independent Repression of Tumor Necrosis Factor (TNF) α-stimulated Interleukin (IL)-6 Expression by the Glucocorticoid Receptor: A POTENTIAL MECHANISM FOR PROTECTION AGAINST AN EXCESSIVE INFLAMMATORY RESPONSE

TNFα signaling and cytokine levels play a crucial role in cervical immunity and the host response to infections. We investigated the role of liganded and unliganded glucocorticoid receptor (GR) in IL-6 and IL-8 gene regulation in response to TNFα in the End1/E6E7 immortalized human endocervical epit...

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Detalhes bibliográficos
Main Authors: Verhoog, Nicolette J. D., Du Toit, Andrea, Avenant, Chanel, Hapgood, Janet P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103308/
https://ncbi.nlm.nih.gov/pubmed/21474440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193672
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