Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line, via mechanisms involving the glucocorticoid receptor, increased CD4/CD8 ratios and CCR5 levels

High usage of progestin-only injectable contraceptives, which include the intramuscular injectables depo-medroxyprogesterone acetate (DMPA-IM, Depo-Provera) and norethisterone (NET) enanthate (NET-EN or Nur-Isterate), correlates worldwide with areas of high HIV-1 prevalence. Epidemiological data sho...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maritz, Michelle F., Ray, Roslyn M., Bick, Alexis J., Tomasicchio, Michele, Woodland, John G., Govender, Yashini, Avenant, Chanel, Hapgood, Janet P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919616/
https://ncbi.nlm.nih.gov/pubmed/29698514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196043
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