Discovery of a Novel Series of Thienopyrimidine as Highly Potent and Selective PI3K Inhibitors

by Han, Fangbin, Lin, Songwen, Liu, Peng, Liu, Xiujie, Tao, Jing, Deng, Xiaobing, Yi, Chongqin, Xu, Heng
Published in ACS Med Chem Lett (2015)

Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth

by Ren, Chunyan, Zhang, Guangtao, Han, Fangbin, Fu, Shibo, Cao, Yingdi, Zhang, Fan, Zhang, Qiang, Meslamani, Jamel, Xu, Yaoyao, Ji, Donglei, Cao, Lingling, Zhou, Qian, Cheung, Ka-lung, Sharma, Rajal, Babault, Nicolas, Yi, Zhengzi, Zhang, Weijia, Walsh, Martin J., Zeng, Lei, Zhou, Ming-Ming
Published in Proc Natl Acad Sci U S A (2018)

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

by Wang, Yonghui, Cai, Wei, Cheng, Yaobang, Yang, Ting, Liu, Qian, Zhang, Guifeng, Meng, Qinghua, Han, Fangbin, Huang, Yafei, Zhou, Ling, Xiang, Zhijun, Zhao, Yong-Gang, Xu, Yan, Cheng, Ziqiang, Lu, Sijie, Wu, Qianqian, Xiang, Jia-Ning, Elliott, John D., Leung, Stewart, Ren, Feng, Lin, Xichen
Published in ACS Med Chem Lett (2015)