Genetic Association of Phosphodiesterases With Human Cognitive Performance

Por Gurney, Mark E.
Publicado no Front Mol Neurosci (2019)

The Use of Facebook Advertising to Recruit Healthy Elderly People for a Clinical Trial: Baseline Metrics

Por Cowie, Julie M, Gurney, Mark E
Publicado no JMIR Res Protoc (2018)

Structural Basis for the Design of Selective Phosphodiesterase 4B Inhibitors

Por Fox, David, Burgin, Alex B., Gurney, Mark E.
Publicado em 2013

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

Por Gurney, Mark E., D’Amato, Emily C., Burgin, Alex B.
Publicado no Neurotherapeutics (2014)

Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

Por Zhou, Mengshi, Xu, Rong, Kaelber, David C., Gurney, Mark E.
Publicado no PLoS One (2020)

Formation of high molecular weight complexes of mutant Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis

Por Johnston, Jennifer A., Dalton, Muffie J., Gurney, Mark E., Kopito, Ron R.
Publicado em 2000

Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury

Por Wilson, Nicole M., Gurney, Mark E., Dietrich, W. Dalton, Atkins, Coleen M.
Publicado no PLoS One (2017)

Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)

Por Gurney, Mark E., Cogram, Patricia, Deacon, Robert M, Rex, Christopher, Tranfaglia, Michael
Publicado no Sci Rep (2017)

Mutant Cu,Zn superoxide dismutase in motor neuron disease

Por Gurney, Mark E., Liu, Rugao, Althaus, John S., Hall, Edward D., Becker, David A.
Publicado em 1998

The effect of diet on the protective action of D156844 observed in spinal muscular atrophy mice

Por Butchbach, Matthew E. R., Singh, Jasbir, Gurney, Mark E., Burghes, Arthur H. M.
Publicado em 2014

PDE4 Subtypes in Cancer

Por Lai, Samuel Hsien, Zervoudakis, Guston, Chou, Jesse, Gurney, Mark E., Quesnelle, Kelly M.
Publicado no Oncogene (2020)

Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

Por Zhang, Chong, Xu, Ying, Zhang, Han-Ting, Gurney, Mark E., O’Donnell, James M.
Publicado no Sci Rep (2017)

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

Por Hagen, Timothy J., Mo, Xuesheng, Burgin, Alex B., Fox, David, Zhang, Zheng, Gurney, Mark E.
Publicado em 2014

A Negative Allosteric Modulator of PDE4D Enhances Learning after Traumatic Brain Injury

Por Titus, David J., Wilson, Nicole M., Alcazar, Oscar, Calixte, Dale A., Dietrich, W. Dalton, Gurney, Mark E., Atkins, Coleen M.
Publicado no Neurobiol Learn Mem (2017)

Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor

Por Cui, Su-Ying, Yang, Ming-Xin, Zhang, Yong-He, Zheng, Victor, Zhang, Han-Ting, Gurney, Mark E., Xu, Ying, O’Donnell, James M.
Publicado no J Pharmacol Exp Ther (2019)

A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway

Por Wang, Yulu, Gao, Shichao, Zheng, Victor, Chen, Ling, Ma, Min, Shen, Shichen, Qu, Jun, Zhang, Hanting, Gurney, Mark E., O’Donnell, James M., Xu, Ying
Publicado no Front Cell Dev Biol (2020)

Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

Por Titus, David J., Wilson, Nicole M., Freund, Julie E., Carballosa, Melissa M., Sikah, Kevin E., Furones, Concepcion, Dietrich, W. Dalton, Gurney, Mark E., Atkins, Coleen M.
Publicado no J Neurosci (2016)

Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

Por Zhang, Chong, Xu, Ying, Chowdhary, Anirudh, Fox, David, Gurney, Mark E., Zhang, Han-Ting, Auerbach, Benjamin D., Salvi, Richard J., Yang, Mingxin, Li, Gaowen, O’Donnell, James M.
Publicado no Neuropsychopharmacology (2018)

Neuregulin1 (NRG1) Signaling through Fyn Modulates NMDA Receptor Phosphorylation: Differential Synaptic Function in NRG1(+/−) Knock-Outs Compared with Wild-Type Mice

Por Bjarnadottir, Maria, Misner, Dinah L., Haverfield-Gross, Sascha, Bruun, Silas, Helgason, Vignir G., Stefansson, Hreinn, Sigmundsson, Arnar, Firth, David R., Nielsen, Berit, Stefansdottir, Ragnheidur, Novak, Thomas J., Stefansson, Kari, Gurney, Mark E., Andresson, Thorkell
Publicado no J Neurosci (2007)

Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography

Por Davies, Douglas R., Mamat, Bjorn, Magnusson, Olafur T., Christensen, Jeff, Haraldsson, Magnus H., Mishra, Rama, Pease, Brian, Hansen, Erik, Singh, Jasbir, Zembower, David, Kim, Hidong, Kiselyov, Alex S., Burgin, Alex B., Gurney, Mark E., Stewart, Lance J.
Publicado em 2009