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Structural Basis for the Design of Selective Phosphodiesterase 4B Inhibitors
Phosphodiesterase-4B (PDE4B) regulates the pro-inflammatory Toll Receptor –Tumor Necrosis Factor α (TNFα) pathway in monocytes, macrophages and microglial cells. As such, it is an important, although under-exploited molecular target for anti-inflammatory drugs. This is due in part to the difficulty...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4057648/ https://ncbi.nlm.nih.gov/pubmed/24361374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.12.003 |
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