Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: Implications for an intracellular distribution-based drug interaction

Por Funk, Ryan S., Krise, Jeffrey P.
Publicado em 2012

Reverse Translation in Advancing Pharmacotherapy in Pediatric Rheumatology: A Logical Approach in Rare Diseases with Limited Resources

Por Becker, Mara L., Funk, Ryan S.
Publicado no Clin Transl Sci (2017)

3019 Metabolomic Markers of Methotrexate Response in Juvenile Idiopathic Arthritis

Por Funk, Ryan Sol, Becker, Mara
Publicado no J Clin Transl Sci (2019)

Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro

Por Funk, Ryan S., Singh, Rakesh K., Becker, Mara L.
Publicado no Clin Transl Sci (2019)

Mechanisms of amine accumulation in, and egress from, lysosomes

Por Goldman, Stephen DB, Funk, Ryan S, Rajewski, Roger A, Krise, Jeffrey P
Publicado em 2009

Low-Dose Methotrexate Results in the Selective Accumulation of Aminoimidazole Carboxamide Ribotide in an Erythroblastoid Cell Line

Por Funk, Ryan S., van Haandel, Leon, Becker, Mara L., Leeder, J. Steven
Publicado em 2013

Folate Depletion and Increased Glutamation in Juvenile Idiopathic Arthritis Patients Treated with Methotrexate

Por Funk, Ryan S., van Haandel, Leon, Leeder, J. Steven, Becker, Mara L.
Publicado no Arthritis Rheumatol (2014)

Altered Folate Homeostasis in Children with Down syndrome: A Potential Basis for Enhanced Methotrexate Toxicity

Por Funk, Ryan S., Talib, Nasreen, Zimmerman, Kanecia, van Haandel, Leon, Becker, Mara L.
Publicado no J Pediatr (2020)

Facing Real-World Challenges of Immunogenicity in Pediatric Inflammatory Bowel Disease

Por Gress, Kyle, Bass, Julie A., Funk, Ryan S., Morrow, Ryan P., Hasenkamp, Rachel, Shakhnovich, Valentina
Publicado no Front Immunol (2020)

Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)

Por Kazmi, Faraz, Hensley, Tiffini, Pope, Chad, Funk, Ryan S., Loewen, Greg J., Buckley, David B., Parkinson, Andrew
Publicado em 2013

Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model

Por Singh, Rakesh K., van Haandel, Leon, Kiptoo, Paul, Becker, Mara L., Siahaan, Teruna J., Funk, Ryan S.
Publicado no Eur J Pharmacol (2019)

Mast Cell Degranulation Decreases Lipopolysaccharide-Induced Aortic Gene Expression and Systemic Levels of Interleukin-6 In Vivo

Por Springer, Jason M., Raveendran, Vineesh V., Zhang, Mingcai, Funk, Ryan, Smith, Donald D., Maz, Mehrdad, Dileepan, Kottarappat N.
Publicado no Mediators Inflamm (2019)

Variability in Potency Among Commercial Preparations of Berberine

Por Funk, Ryan S., Singh, Rakesh K., Winefield, Robert D., Kandel, Sylvie E., Ruisinger, Janelle F., Moriarty, Patrick M., Backes, James M.
Publicado no J Diet Suppl (2017)

Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP

Por Singh, Rakesh K., van Haandel, Leon, Heruth, Daniel P., Ye, Shui Q., Leeder, J. Steven, Becker, Mara L., Funk, Ryan S.
Publicado no J Pharmacol Exp Ther (2018)

Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice

Por Funk, Ryan K., Maxwell, Taylor J., Izumi, Masayo, Edwin, Deepa, Kreisel, Friederike, Ley, Timothy J., Cheverud, James M., Graubert, Timothy A.
Publicado em 2008

Recurrent adult-onset hypophyseal Langerhans cell histiocytosis after radiotherapy: a case report

Por Funk, Ryan K, Ferraro, Daniel J, Perrin, Richard J, Hurth, Kyle M, Stephens, John J, Mansur, David B, Chicoine, Michael R, Simpson, Joseph R, Jaboin, Jerry J
Publicado em 2012

Immunogenicity in Clinical Practice and Drug Development: When is it Significant?

Por Shakhnovich, Valentina, Meibohm, Bernd, Rosenberg, Amy, Kierzek, Andrzej M., Hasenkamp, Rachel, Funk, Ryan S., Thalhauser, Craig J., van der Graaf, Piet H., Wang, Yow‐Ming C., Hamuro, Lora
Publicado no Clin Transl Sci (2019)

Precision Pharmacotherapy: Integrating Pharmacogenomics into Clinical Pharmacy Practice

Por Hicks, J. Kevin, Aquilante, Christina L., Dunnenberger, Henry M., Gammal, Roseann S., Funk, Ryan S., Aitken, Samuel L., Bright, David R., Coons, James C., Dotson, Kierra M., Elder, Christopher T., Groff, Lindsey T., Lee, James C.
Publicado no J Am Coll Clin Pharm (2019)

A retrospective analysis of survival and prognostic factors after stereotactic radiosurgery for aggressive meningiomas

Por Ferraro, Daniel J, Funk, Ryan K, Blackett, John William, Ju, Michelle R, DeWees, Todd A, Chicoine, Michael R, Dowling, Joshua L, Rich, Keith M, Drzymala, Robert E, Zoberi, Imran, Simpson, Joseph R, Jaboin, Jerry J
Publicado em 2014

The Rare Cancer Network: Ongoing Studies and Future Strategy

Por Ozsahin, Mahmut, Mirimanoff, René-Olivier, Thariat, Juliette, Sun, Xu Shan, Atalar, Banu, Lassen-Ramshad, Yasmin, Ugurluer, Gamze, Krishnan, Sunil, Hallemeier, Christopher, Houtte, Paul Van, Krengli, Marco, Zhang, Lan Jun, Chang, Kenneth, Funk, Ryan, Rooney, Jessica, Miller, Robert C.
Publicado em 2014