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Altered Folate Homeostasis in Children with Down syndrome: A Potential Basis for Enhanced Methotrexate Toxicity

Methotrexate (MTX) is used to treat autoimmune and oncologic diseases in children with Down syndrome (DS). However, increased MTX-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with DS as a potential...

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Bibliografiske detaljer
Udgivet i:J Pediatr
Main Authors: Funk, Ryan S., Talib, Nasreen, Zimmerman, Kanecia, van Haandel, Leon, Becker, Mara L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247922/
https://ncbi.nlm.nih.gov/pubmed/32111377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2020.01.032
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