Approach to evaluating tumor mutational burden in routine clinical practice

by Truesdell, John, Miller, Vincent A., Fabrizio, David
Published in Transl Lung Cancer Res (2018)

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies

by Hartmaier, Ryan J., Charo, Jehad, Fabrizio, David, Goldberg, Michael E., Albacker, Lee A., Pao, William, Chmielecki, Juliann
Published in Genome Med (2017)

EAPH-06. HYPERMUTANT PEDIATRIC HIGH GRADE GLIOMAS ARE DRIVEN BY RAS/MAPK MUTATIONS AND RESPOND TO MEK INHIBITION

by Campbell, Brittany B, Morgenstern, Daniel A, Lipman, Tatiana, Fabrizio, David, Shlien, Adam, Bouffet, Eric, Hawkins, Cynthia, Tabori, Uri
Published in Neuro Oncol (2018)

A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin

by Wensel, David, Sun, Yongnian, Davis, Jonathan, Li, Zhufang, Zhang, Sharon, McDonagh, Thomas, Fabrizio, David, Cockett, Mark, Krystal, Mark
Published in J Virol (2018)

Evidence‐Based Development and Clinical Use of Precision Oncology Therapeutics

by Comment, Leah A., Ward, Ashley F., Schrock, Alexa B., Fabrizio, David, Venstrom, Jeffrey M., Hegde, Priti S., Alexander, Brian M.
Published in Clin Pharmacol Ther (2020)

Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity

by Wensel, David, Sun, Yongnian, Li, Zhufang, Zhang, Sharon, Picarillo, Caryn, McDonagh, Thomas, Fabrizio, David, Cockett, Mark, Krystal, Mark, Davis, Jonathan
Published in Antimicrob Agents Chemother (2017)

Tumor Mutational Burden as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors: A Review of Current Evidence

by Klempner, Samuel J., Fabrizio, David, Bane, Shalmali, Reinhart, Marcia, Peoples, Tim, Ali, Siraj M., Sokol, Ethan S., Frampton, Garrett, Schrock, Alexa B., Anhorn, Rachel, Reddy, Prasanth
Published in Oncologist (2019)

Prevalence of established and emerging biomarkers of immune checkpoint inhibitor response in advanced hepatocellular carcinoma

by Ang, Celina, Klempner, Samuel J., Ali, Siraj M., Madison, Russell, Ross, Jeffrey S., Severson, Eric A., Fabrizio, David, Goodman, Aaron, Kurzrock, Razelle, Suh, James, Millis, Sherri Z.
Published in Oncotarget (2019)

Circulating Tumor DNA Identifies EGFR Co-Amplification as a Mechanism of Resistance to Crizotinib in a Patient with Advanced MET-Amplified Lung Adenocarcinoma

by Dagogo-Jack, Ibiayi, Fabrizio, David, Lennerz, Jochen, Schrock, Alexa B., Young, Lauren, Mino-Kenudson, Man, Digumarthy, Subba R., Heist, Rebecca S., Ali, Siraj M., Miller, Vincent A., Shaw, Alice T.
Published in J Thorac Oncol (2017)

Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors

by Goodman, Aaron M., Piccioni, David, Kato, Shumei, Boichard, Amélie, Wang, Huan-You, Frampton, Garrett, Lippman, Scott M., Connelly, Caitlin, Fabrizio, David, Miller, Vincent, Sicklick, Jason K., Kurzrock, Razelle
Published in JAMA Oncol (2018)

Prevalence of High Tumor Mutational Burden and Association With Survival in Patients With Less Common Solid Tumors

by Shao, Changxia, Li, Gerald, Huang, Lingkang, Pruitt, Scott, Castellanos, Emily, Frampton, Garrett, Carson, Kenneth R., Snow, Tamara, Singal, Gaurav, Fabrizio, David, Alexander, Brian M., Jin, Fan, Zhou, Wei
Published in JAMA Netw Open (2020)

DRAGON: A Member of the Repulsive Guidance Molecule-Related Family of Neuronal- and Muscle-Expressed Membrane Proteins Is Regulated by DRG11 and Has Neuronal Adhesive Properties

by Samad, Tarek A., Srinivasan, Ashok, Karchewski, Laurie A., Jeong, Sung-Jin, Campagna, Jason A., Ji, Ru-Rong, Fabrizio, David A., Zhang, Ying, Lin, Herbert Y., Bell, Esther, Woolf, Clifford J.
Published in J Neurosci (2004)

High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers

by Riviere, Paul, Goodman, Aaron M, Okamura, Ryosuke, Barkauskas, Donald A., Whitchurch, Theresa J, Lee, Suzanna, Khalid, Noor, Collier, Rachel, Mareboina, Manvita, Frampton, Garrett M., Fabrizio, David, Sharabi, Andrew B., Kato, Shumei, Kurzrock, Razelle
Published in Mol Cancer Ther (2020)

BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy

by Johnson, Douglas B., Childress, Merrida A., Chalmers, Zachary R., Frampton, Garrett M., Ali, Siraj M., Rubinstein, Samuel M., Fabrizio, David, Ross, Jeffrey S., Balasubramanian, Sohail, Miller, Vincent A., Stephens, Philip J., Sosman, Jeffrey A., Lovly, Christine M.
Published in Pigment Cell Melanoma Res (2017)

Comprehensive Genomic Profiling of Hodgkin Lymphoma Reveals Recurrently Mutated Genes and Increased Mutation Burden

by Liang, Winnie S., Vergilio, Jo‐Anne, Salhia, Bodour, Huang, Helen J., Oki, Yasuhiro, Garrido‐Laguna, Ignacio, Park, Haeseong, Westin, Jason R., Meric‐Bernstam, Funda, Fabrizio, David, Miller, Vincent A., Stephens, Philip J., Fanale, Michelle A., Ross, Jeffrey S., Janku, Filip
Published in Oncologist (2018)

Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3

by Ross, Jeffrey S., Fakih, Marwan, Ali, Siraj M., Elvin, Julia A., Schrock, Alexa B., Suh, James, Vergilio, Jo‐Anne, Ramkissoon, Shakti, Severson, Eric, Daniel, Sugganth, Fabrizio, David, Frampton, Garrett, Sun, James, Miller, Vincent A., Stephens, Philip J., Gay, Laurie M.
Published in Cancer (2018)

IMMU-13. LARGE SCALE TUMOR MUTATIONAL BURDEN ANALYSIS OF PEDIATRIC TUMORS PROVIDES A DIAGNOSTIC TOOL FOR GERMLINE PREDISPOSITION AND REVEALS NOVEL CANDIDATES FOR IMMUNE CHECKPOINT...

by Campbell, Brittany B., Angelini, Paola, Fabrizio, David, Elvin, Julia, Light, Nicholas, Bouffet, Eric, Larouche, Valerie, Samuel, David, Stearns, Duncan, Cole, Kristina, Opocher, Enrico, Thomas, Gregory, Sabel, Magnus, George, Ben, Ziegler, David, Lapierre, Norman, Mason, Gary, Magimajrajan, Vanan, Shlien, Adam, Tabori, Uri
Published in Neuro Oncol (2017)

Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition

by Fabrizio, David A., George, Thomas J., Dunne, Richard F., Frampton, Garrett, Sun, James, Gowen, Kyle, Kennedy, Mark, Greenbowe, Joel, Schrock, Alexa B., Hezel, Aram F., Ross, Jeffrey S., Stephens, Phillip J., Ali, Siraj M., Miller, Vincent A., Fakih, Marwan, Klempner, Samuel J.
Published in J Gastrointest Oncol (2018)

HGG-17. TUMOR MUTATIONAL BURDEN ANALYSIS OF PEDIATRIC TUMORS PROVIDES A DIAGNOSTIC TOOL FOR GERMLINE REPLICATION REPAIR DEFICIENCY AND PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBIT...

by Campbell, Brittany B, Light, Nicholas, Fabrizio, David, Bouffet, Eric, Larouche, Valerie, Samuel, David, Stearns, Duncan, Cole, Kristina A, Opocher, Enrico, Thomas, Gregory, Sabel, Magnus, Dirks, Peter, Taylor, Michael, Malkin, David, Albrecht, Steffen, Dudley, Roy, Jabado, Nada, Hawkins, Cynthia, Shlien, Adam, Tabori, Uri
Published in Neuro Oncol (2018)

A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability–High Cases in 67,000 Patient S...

by Trabucco, Sally E., Gowen, Kyle, Maund, Sophia L., Sanford, Eric, Fabrizio, David A., Hall, Michael J., Yakirevich, Evgeny, Gregg, Jeffrey P., Stephens, Phil J., Frampton, Garrett M., Hegde, Priti S., Miller, Vincent A., Ross, Jeffrey S., Hartmaier, Ryan J., Huang, Shih-Min A., Sun, James X.
Published in J Mol Diagn (2019)