Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug‐Drug Interactions or in Special Populat...

por Tse, Susanna, Dowty, Martin E., Menon, Sujatha, Gupta, Pankaj, Krishnaswami, Sriram
Publicado en J Clin Pharmacol (2020)

Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data

por Gupta, Pankaj, Alvey, Christine, Wang, Rong, Dowty, Martin E, Fahmi, Odette A, Walsky, Robert L, Riese, Richard J, Krishnaswami, Sriram
Publicado 2012

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

por Dowty, Martin E., Lin, Tsung H., Jesson, Michael I., Hegen, Martin, Martin, David A., Katkade, Vaibhav, Menon, Sujatha, Telliez, Jean‐Baptiste
Publicado en Pharmacol Res Perspect (2019)

Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study

por Singh, Ravi Shankar P., Pradhan, Vivek, Roberts, Erika S., Scaramozza, Matthew, Kieras, Elizabeth, Gale, Jeremy D., Peeva, Elena, Vincent, Michael S., Banerjee, Anindita, Fensome, Andrew, Dowty, Martin E., Winkle, Peter, Tehlirian, Christopher
Publicado en Clin Transl Sci (2020)

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences

por Gerstenberger, Brian S., Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Fensome, Andrew, Gifford, Roger, Griffor, Matthew C., Hegen, Martin, Hollingshead, Brett D., Knafels, John D., Lin, Tsung H., Smith, James F., Vajdos, Felix F.
Publicado en Sci Rep (2020)

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

por Avery, Lindsay B., Wang, Mengmeng, Kavosi, Mania S., Joyce, Alison, Kurz, Jeffrey C., Fan, Yao-Yun, Dowty, Martin E., Zhang, Minlei, Zhang, Yiqun, Cheng, Aili, Hua, Fei, Jones, Hannah M., Neubert, Hendrik, Polzer, Robert J., O'Hara, Denise M.
Publicado en MAbs (2016)

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

por Meyer Debra M, Jesson Michael I, Li Xiong, Elrick Mollisa M, Funckes-Shippy Christie L, Warner James D, Gross Cindy J, Dowty Martin E, Ramaiah Shashi K, Hirsch Jeffrey L, Saabye Matthew J, Barks Jennifer L, Kishore Nandini, Morris Dale L
Publicado 2010-08-01

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

por Meyer, Debra M, Jesson, Michael I, Li, Xiong, Elrick, Mollisa M, Funckes-Shippy, Christie L, Warner, James D, Gross, Cindy J, Dowty, Martin E, Ramaiah, Shashi K, Hirsch, Jeffrey L, Saabye, Matthew J, Barks, Jennifer L, Kishore, Nandini, Morris, Dale L
Publicado 2010

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

por Ghoreschi, Kamran, Jesson, Michael I., Li, Xiong, Lee, Jamie L., Ghosh, Sarbani, Alsup, Jason W., Warner, James D., Tanaka, Masao, Steward-Tharp, Scott M., Gadina, Massimo, Thomas, Craig, Minnerly, John C., Storer, Chad E., LaBranche, Timothy P., Radi, Zaher A., Dowty, Martin E., Head, Richard D., Meyer, Debra M., Kishore, Nandini, O'Shea, John J.
Publicado 2011

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

por Carron, Chris P., Trujillo, John I., Olson, Kirk L., Huang, Wei, Hamper, Bruce C., Dice, Tom, Neal, Bradley E., Pelc, Matthew J., Day, Jacqueline E., Rohrer, Douglas C., Kiefer, James R., Moon, Joseph B., Schweitzer, Barbara A., Blake, Tanisha D., Turner, Steve R., Woerndle, Rhonda, Case, Brenda L., Bono, Christine P., Dilworth, Vickie M., Funckes-Shippy, Christie L., Hood, Becky L., Jerome, Gina M., Kornmeier, Christine M., Radabaugh, Melissa R., Williams, Melanie L., Davies, Michael S., Wegner, Craig D., Welsch, Dean J., Abraham, William M., Warren, Chad J., Dowty, Martin E., Hua, Fengmei, Zutshi, Anup, Yang, Jerry Z., Thorarensen, Atli
Publicado 2010