Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung(−/−)Msh2(−/−)...

por Kemmerich, Kristin, Dingler, Felix A., Rada, Cristina, Neuberger, Michael S.
Publicado em 2012

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation

por Dingler, Felix A., Kemmerich, Kristin, Neuberger, Michael S., Rada, Cristina
Publicado em 2014

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

por Baud, Matthias G.J., Bauer, Matthias R., Verduci, Lorena, Dingler, Felix A., Patel, Ketan J., Horil Roy, Deeptee, Joerger, Andreas C., Fersht, Alan R.
Publicado no Eur J Med Chem (2018)

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

por Bauer, Matthias R, Jones, Rhiannon N, Tareque, Raysa K, Springett, Bradley, Dingler, Felix A, Verduci, Lorena, Patel, Ketan J, Fersht, Alan R, Joerger, Andreas C, Spencer, John
Publicado no Future Med Chem (2019)

Single-Cell RNA Sequencing Reveals T Helper Cells Synthesizing Steroids De Novo to Contribute to Immune Homeostasis

por Mahata, Bidesh, Zhang, Xiuwei, Kolodziejczyk, Aleksandra A., Proserpio, Valentina, Haim-Vilmovsky, Liora, Taylor, Angela E., Hebenstreit, Daniel, Dingler, Felix A., Moignard, Victoria, Göttgens, Berthold, Arlt, Wiebke, McKenzie, Andrew N.J., Teichmann, Sarah A.
Publicado em 2014

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

por Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.
Publicado no Nature (2017)

Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

por Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.
Publicado no Nature (2017)

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1

por Alsøe, Lene, Sarno, Antonio, Carracedo, Sergio, Domanska, Diana, Dingler, Felix, Lirussi, Lisa, SenGupta, Tanima, Tekin, Nuriye Basdag, Jobert, Laure, Alexandrov, Ludmil B., Galashevskaya, Anastasia, Rada, Cristina, Sandve, Geir Kjetil, Rognes, Torbjørn, Krokan, Hans E., Nilsen, Hilde
Publicado no Sci Rep (2017)

The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

por Safavi, Shiva, Larouche, Ariane, Zahn, Astrid, Patenaude, Anne-Marie, Domanska, Diana, Dionne, Kiersten, Rognes, Torbjørn, Dingler, Felix, Kang, Seong-Kwi, Liu, Yan, Johnson, Nathalie, Hébert, Josée, Verdun, Ramiro E, Rada, Cristina A, Vega, Francisco, Nilsen, Hilde, Di Noia, Javier M
Publicado no NAR Cancer (2020)

The uracil–DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

por Safavi, Shiva, Larouche, Ariane, Zahn, Astrid, Patenaude, Anne-Marie, Domanska, Diana, Dionne, Kiersten, Rognes, Torbjørn, Dingler, Felix, Kang, Seong-Kwi, Liu, Yan, Johnson, Nathalie, Hébert, Josée, Verdun, Ramiro E, Rada, Cristina A, Vega, Francisco, Nilsen, Hilde, Noia, Javier M D
Publicado no NAR Cancer (2021)

Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

por Wang, Meng, Brandt, Laura T.L., Wang, Xiaonan, Russell, Holly, Mitchell, Emily, Kamimae-Lanning, Ashley N., Brown, Jill M., Dingler, Felix A., Garaycoechea, Juan I., Isobe, Tomoya, Kinston, Sarah J., Gu, Muxin, Vassiliou, George S., Wilson, Nicola K., Göttgens, Berthold, Patel, Ketan J.
Publicado no Mol Cell (2023)

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

por Dingler, Felix A., Wang, Meng, Mu, Anfeng, Millington, Christopher L., Oberbeck, Nina, Watcham, Sam, Pontel, Lucas B., Kamimae-Lanning, Ashley N., Langevin, Frederic, Nadler, Camille, Cordell, Rebecca L., Monks, Paul S., Yu, Rui, Wilson, Nicola K., Hira, Asuka, Yoshida, Kenichi, Mori, Minako, Okamoto, Yusuke, Okuno, Yusuke, Muramatsu, Hideki, Shiraishi, Yuichi, Kobayashi, Masayuki, Moriguchi, Toshinori, Osumi, Tomoo, Kato, Motohiro, Miyano, Satoru, Ito, Etsuro, Kojima, Seiji, Yabe, Hiromasa, Yabe, Miharu, Matsuo, Keitaro, Ogawa, Seishi, Göttgens, Berthold, Hodskinson, Michael R.G., Takata, Minoru, Patel, Ketan J.
Publicado no Mol Cell (2020)