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Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also release formaldehyde, a potent protein and DNA crosslinking agent that organisms produce in substantial quanti...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5714256/ https://ncbi.nlm.nih.gov/pubmed/28813411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23481 |
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