Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also release formaldehyde, a potent protein and DNA crosslinking agent that organisms produce in substantial quanti...

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Publicado en:Nature
Main Authors: Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714256/
https://ncbi.nlm.nih.gov/pubmed/28813411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23481
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