Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

Por Rappuoli, Rino, Bottomley, Matthew J., D’Oro, Ugo, Finco, Oretta, De Gregorio, Ennio
Publicado no J Exp Med (2016)

Src Kinases Are Required for a Balanced Production of IL-12/IL-23 in Human Dendritic Cells Activated by Toll-Like Receptor Agonists

Por Kuka, Mirela, Baronio, Roberta, Valentini, Sara, Monaci, Elisabetta, Muzzi, Alessandro, Aprea, Susanna, De Gregorio, Ennio, D'Oro, Ugo
Publicado em 2010

CD8 T-cell priming upon mRNA vaccination is restricted to bone-marrow-derived antigen-presenting cells and may involve antigen transfer from myocytes

Por Lazzaro, Sandra, Giovani, Cinzia, Mangiavacchi, Simona, Magini, Diletta, Maione, Domenico, Baudner, Barbara, Geall, Andrew J, De Gregorio, Ennio, D’Oro, Ugo, Buonsanti, Cecilia
Publicado no Immunology (2015)

Development and Application of a Novel SPE-Method for Bioassay-Guided Fractionation of Marine Extracts

Por Cutignano, Adele, Nuzzo, Genoveffa, Ianora, Adrianna, Luongo, Elvira, Romano, Giovanna, Gallo, Carmela, Sansone, Clementina, Aprea, Susanna, Mancini, Francesca, D’Oro, Ugo, Fontana, Angelo
Publicado no Mar Drugs (2015)

Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders

Por Rosa, Domenico, Saletti, Giulietta, De Gregorio, Ennio, Zorat, Francesca, Comar, Consuelo, D'Oro, Ugo, Nuti, Sandra, Houghton, Michael, Barnaba, Vincenzo, Pozzato, Gabriele, Abrignani, Sergio
Publicado em 2005

Modulation of Endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications: RELATIVE ACTIVATION OF TLR4 AND TLR2 PATHWAYS IN DIFFERENT...

Por Rossi, Omar, Pesce, Isabella, Giannelli, Carlo, Aprea, Susanna, Caboni, Mariaelena, Citiulo, Francesco, Valentini, Sara, Ferlenghi, Ilaria, MacLennan, Calman Alexander, D'Oro, Ugo, Saul, Allan, Gerke, Christiane
Publicado em 2014

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

Por Crotta, Stefania, Stilla, Annalisa, Wack, Andreas, D'Andrea, Annalisa, Nuti, Sandra, D'Oro, Ugo, Mosca, Marta, Filliponi, Franco, Brunetto, R. Maurizia, Bonino, Ferruccio, Abrignani, Sergio, Valiante, Nicholas M.
Publicado em 2002

A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells

Por Santone, Melissa, Aprea, Susanna, Wu, Tom Y H, Cooke, Michael P, Mbow, M Lamine, Valiante, Nicholas M, Rush, James S, Dougan, Stephanie, Avalos, Ana, Ploegh, Hidde, De Gregorio, Ennio, Buonsanti, Cecilia, D'Oro, Ugo
Publicado no Hum Vaccin Immunother (2015)

Novel adjuvant Alum-TLR7 significantly potentiates immune response to glycoconjugate vaccines

Por Buonsanti, Cecilia, Balocchi, Cristiana, Harfouche, Carole, Corrente, Federica, Galli Stampino, Luisa, Mancini, Francesca, Tontini, Marta, Malyala, Padma, Bufali, Simone, Baudner, Barbara, De Gregorio, Ennio, Valiante, Nicholas M., O’Hagan, Derek T., Rappuoli, Rino, D’Oro, Ugo
Publicado no Sci Rep (2016)

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

Por Seubert, Anja, Calabro, Samuele, Santini, Laura, Galli, Barbara, Genovese, Alessia, Valentini, Sara, Aprea, Susanna, Colaprico, Annalisa, D'Oro, Ugo, Giuliani, Marzia M., Pallaoro, Michele, Pizza, Mariagrazia, O'Hagan, Derek T., Wack, Andreas, Rappuoli, Rino, De Gregorio, Ennio
Publicado em 2011

The Human Pathogen Streptococcus pyogenes Releases Lipoproteins as Lipoprotein-rich Membrane Vesicles

Por Biagini, Massimiliano, Garibaldi, Manuela, Aprea, Susanna, Pezzicoli, Alfredo, Doro, Francesco, Becherelli, Marco, Taddei, Anna Rita, Tani, Chiara, Tavarini, Simona, Mora, Marirosa, Teti, Giuseppe, D'Oro, Ugo, Nuti, Sandra, Soriani, Marco, Margarit, Immaculada, Rappuoli, Rino, Grandi, Guido, Norais, Nathalie
Publicado no Mol Cell Proteomics (2015)

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

Por Vulpis, Elisabetta, Cecere, Francesca, Molfetta, Rosa, Soriani, Alessandra, Fionda, Cinzia, Peruzzi, Giovanna, Caracciolo, Giulio, Palchetti, Sara, Masuelli, Laura, Simonelli, Lucilla, D'Oro, Ugo, Abruzzese, Maria Pia, Petrucci, Maria Teresa, Ricciardi, Maria Rosaria, Paolini, Rossella, Cippitelli, Marco, Santoni, Angela, Zingoni, Alessandra
Publicado no Oncoimmunology (2017)

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

Por Knudsen, Niels Peter H., Olsen, Anja, Buonsanti, Cecilia, Follmann, Frank, Zhang, Yuan, Coler, Rhea N., Fox, Christopher B., Meinke, Andreas, D´Oro, Ugo, Casini, Daniele, Bonci, Alessandra, Billeskov, Rolf, De Gregorio, Ennio, Rappuoli, Rino, Harandi, Ali M., Andersen, Peter, Agger, Else Marie
Publicado no Sci Rep (2016)

DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells

Por Cavalieri, Duccio, Rivero, Damariz, Beltrame, Luca, Buschow, Sonja I, Calura, Enrica, Rizzetto, Lisa, Gessani, Sandra, Gauzzi, Maria C, Reith, Walter, Baur, Andreas, Bonaiuti, Roberto, Brandizi, Marco, De Filippo, Carlotta, D'Oro, Ugo, Draghici, Sorin, Dunand-Sauthier, Isabelle, Gatti, Evelina, Granucci, Francesca, Gündel, Michaela, Kramer, Matthijs, Kuka, Mirela, Lanyi, Arpad, Melief, Cornelis JM, van Montfoort, Nadine, Ostuni, Renato, Pierre, Philippe, Popovici, Razvan, Rajnavolgyi, Eva, Schierer, Stephan, Schuler, Gerold, Soumelis, Vassili, Splendiani, Andrea, Stefanini, Irene, Torcia, Maria G, Zanoni, Ivan, Zollinger, Raphael, Figdor, Carl G, Austyn, Jonathan M
Publicado em 2010