Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

The immune response against hepatitis C virus (HCV) is rarely effective at clearing the virus, resulting in ∼170 million chronic HCV infections worldwide. Here we report that ligation of an HCV receptor (CD81) inhibits natural killer (NK) cells. Cross-linking of CD81 by the major envelope protein of...

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Detalhes bibliográficos
Main Authors: Crotta, Stefania, Stilla, Annalisa, Wack, Andreas, D'Andrea, Annalisa, Nuti, Sandra, D'Oro, Ugo, Mosca, Marta, Filliponi, Franco, Brunetto, R. Maurizia, Bonino, Ferruccio, Abrignani, Sergio, Valiante, Nicholas M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196014/
https://ncbi.nlm.nih.gov/pubmed/11781363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011124
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