Modulation of Endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications: RELATIVE ACTIVATION OF TLR4 AND TLR2 PATHWAYS IN DIFFERENT MUTANTS

Outer membrane particles from Gram-negative bacteria are attractive vaccine candidates as they present surface antigens in their natural context. We previously developed a high yield production process for genetically derived particles, called generalized modules for membrane antigens (GMMA), from S...

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Detalhes bibliográficos
Main Authors: Rossi, Omar, Pesce, Isabella, Giannelli, Carlo, Aprea, Susanna, Caboni, Mariaelena, Citiulo, Francesco, Valentini, Sara, Ferlenghi, Ilaria, MacLennan, Calman Alexander, D'Oro, Ugo, Saul, Allan, Gerke, Christiane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155660/
https://ncbi.nlm.nih.gov/pubmed/25023285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566570
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