Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

by Chowdhry, Sudhir, Zhang, Yiguo, McMahon, Michael, Sutherland, Calum, Cuadrado, Antonio, Hayes, John D.
Published 2012

SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

by Rada, Patricia, Rojo, Ana I., Chowdhry, Sudhir, McMahon, Michael, Hayes, John D., Cuadrado, Antonio
Published 2011

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

by Deighton, Ruth F., Márkus, Nóra M., Al-Mubarak, Bashayer, Bell, Karen F. S., Papadia, Sofia, Meakin, Paul J., Chowdhry, Sudhir, Hayes, John D., Hardingham, Giles E.
Published 2014

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

by Bell, Karen F., Al-Mubarak, Bashayer, Fowler, Jill H., Baxter, Paul S., Gupta, Kunal, Tsujita, Tadayuki, Chowdhry, Sudhir, Patani, Rickie, Chandran, Siddharthan, Horsburgh, Karen, Hayes, John D., Hardingham, Giles E.
Published 2010

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Resp...

by Meakin, Paul J., Chowdhry, Sudhir, Sharma, Ritu S., Ashford, Fiona B., Walsh, Shaun V., McCrimmon, Rory J., Dinkova-Kostova, Albena T., Dillon, John F., Hayes, John D., Ashford, Michael L. J.
Published 2014

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodeling

by Chowdhry, Sudhir, Zanca, Ciro, Rajkumar, Utkrisht, Koga, Tomoyuki, Diao, Yarui, Raviram, Ramya, Liu, Feng, Turner, Kristen, Yang, Huijun, Brunk, Elizabeth, Bi, Junfeng, Furnari, Frank, Bafna, Vineet, Ren, Bing, Mischel, Paul S.
Published in Nature (2019)

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

by Dayalan Naidu, Sharadha, Sutherland, Calum, Zhang, Ying, Risco, Ana, de la Vega, Laureano, Caunt, Christopher J., Hastie, C. James, Lamont, Douglas J., Torrente, Laura, Chowdhry, Sudhir, Benjamin, Ivor J., Keyse, Stephen M., Cuenda, Ana, Dinkova-Kostova, Albena T.
Published in Mol Cell Biol (2016)

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

by Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.
Published in Nat Commun (2015)

Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling

by Bi, Junfeng, Ichu, Taka-Aki, Zanca, Ciro, Yang, Huijun, Zhang, Wei, Gu, Yuchao, Chowdhry, Sudhir, Reed, Alex, Ikegami, Shiro, Turner, Kristen M., Zhang, Wenjing, Villa, Genaro R., Wu, Sihan, Quehenberger, Oswald, Yong, William H., Kornblum, Harley I., Rich, Jeremy N., Cloughesy, Timothy F., Cavenee, Webster K., Furnari, Frank B., Cravatt, Benjamin F., Mischel, Paul S.
Published in Cell Metab (2019)