Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

Por Chowdhry, Sudhir, Zhang, Yiguo, McMahon, Michael, Sutherland, Calum, Cuadrado, Antonio, Hayes, John D.
Publicado em 2012

SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

Por Rada, Patricia, Rojo, Ana I., Chowdhry, Sudhir, McMahon, Michael, Hayes, John D., Cuadrado, Antonio
Publicado em 2011

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

Por Deighton, Ruth F., Márkus, Nóra M., Al-Mubarak, Bashayer, Bell, Karen F. S., Papadia, Sofia, Meakin, Paul J., Chowdhry, Sudhir, Hayes, John D., Hardingham, Giles E.
Publicado em 2014

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Por Bell, Karen F., Al-Mubarak, Bashayer, Fowler, Jill H., Baxter, Paul S., Gupta, Kunal, Tsujita, Tadayuki, Chowdhry, Sudhir, Patani, Rickie, Chandran, Siddharthan, Horsburgh, Karen, Hayes, John D., Hardingham, Giles E.
Publicado em 2010

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Resp...

Por Meakin, Paul J., Chowdhry, Sudhir, Sharma, Ritu S., Ashford, Fiona B., Walsh, Shaun V., McCrimmon, Rory J., Dinkova-Kostova, Albena T., Dillon, John F., Hayes, John D., Ashford, Michael L. J.
Publicado em 2014

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodeling

Por Chowdhry, Sudhir, Zanca, Ciro, Rajkumar, Utkrisht, Koga, Tomoyuki, Diao, Yarui, Raviram, Ramya, Liu, Feng, Turner, Kristen, Yang, Huijun, Brunk, Elizabeth, Bi, Junfeng, Furnari, Frank, Bafna, Vineet, Ren, Bing, Mischel, Paul S.
Publicado no Nature (2019)

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

Por Dayalan Naidu, Sharadha, Sutherland, Calum, Zhang, Ying, Risco, Ana, de la Vega, Laureano, Caunt, Christopher J., Hastie, C. James, Lamont, Douglas J., Torrente, Laura, Chowdhry, Sudhir, Benjamin, Ivor J., Keyse, Stephen M., Cuenda, Ana, Dinkova-Kostova, Albena T.
Publicado no Mol Cell Biol (2016)

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Por Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.
Publicado no Nat Commun (2015)

Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling

Por Bi, Junfeng, Ichu, Taka-Aki, Zanca, Ciro, Yang, Huijun, Zhang, Wei, Gu, Yuchao, Chowdhry, Sudhir, Reed, Alex, Ikegami, Shiro, Turner, Kristen M., Zhang, Wenjing, Villa, Genaro R., Wu, Sihan, Quehenberger, Oswald, Yong, William H., Kornblum, Harley I., Rich, Jeremy N., Cloughesy, Timothy F., Cavenee, Webster K., Furnari, Frank B., Cravatt, Benjamin F., Mischel, Paul S.
Publicado no Cell Metab (2019)