SUBSTRATE-DEPENDENT EFFECTS OF HUMAN ABCB1 CODING POLYMORPHISMS

door Gow, Jason M., Hodges, Laura M., Chinn, Leslie W., Kroetz, Deanna L.
Gepubliceerd in 2008

Evolutionary Conservation of Vertebrate Blood–Brain Barrier Chemoprotective Mechanisms in Drosophila

door Mayer, Fahima, Mayer, Nasima, Chinn, Leslie, Pinsonneault, Robert L., Kroetz, Deanna, Bainton, Roland J.
Gepubliceerd in 2009

Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI

door Jones, Nicholas S., Yoshida, Kenta, Salphati, Laurent, Kenny, Jane R., Durk, Matthew R., Chinn, Leslie W.
Gepubliceerd in Clin Pharmacol Ther (2019)

Steady State Bioequivalence of Generic and Innovator Formulations of Stavudine, Lamivudine, and Nevirapine in HIV-Infected Ugandan Adults

door Byakika-Tusiime, Jayne, Chinn, Leslie W., Oyugi, Jessica H., Obua, Celestino, Bangsberg, David R., Kroetz, Deanna L.
Gepubliceerd in 2008

Population Pharmacokinetics, Efficacy Exposure-response Analysis, and Model-based Meta-analysis of Fenebrutinib in Subjects with Rheumatoid Arthritis

door Chan, Phyllis, Yu, Jiajie, Chinn, Leslie, Prohn, Marita, Huisman, Jan, Matzuka, Brett, Hanley, William, Tuckwell, Katie, Quartino, Angelica
Gepubliceerd in Pharm Res (2020)

Correction to: Population Pharmacokinetics, Efficacy Exposure-response Analysis, and Model-based Meta-analysis of Fenebrutinib in Subjects with Rheumatoid Arthritis

door Chan, Phyllis, Yu, Jiajie, Chinn, Leslie, Prohn, Marita, Huisman, Jan, Matzuka, Brett, Hanley, William, Tuckwell, Katie, Quartino, Angelica
Gepubliceerd in Pharm Res (2020)

Measuring the Overall Genetic Component of Nevirapine Pharmacokinetics and the Role of Selected Polymorphisms: Towards Addressing the Missing Heritability in Pharmacogenetic Phenot...

door Micheli, Janine E., Chinn, Leslie W., Shugarts, Sarah B., Patel, Ashish, Martin, Jeffrey N., Bangsberg, David R., Kroetz, Deanna L.
Gepubliceerd in 2013

Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)

door Hodges, Laura M., Markova, Svetlana M., Chinn, Leslie W., Gow, Jason M., Kroetz, Deanna L., Klein, Teri E., Altman, Russ B.
Gepubliceerd in 2011

Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains

door Kelly, Libusha, Fukushima, Hisayo, Karchin, Rachel, Gow, Jason M, Chinn, Leslie W, Pieper, Ursula, Segal, Mark R, Kroetz, Deanna L, Sali, Andrej
Gepubliceerd in 2010

Response to “Predictable difficulty or difficulty to predict”

door Kelly, Libusha, Fukushima, Hisayo, Karchin, Rachel, Gow, Jason M, Chinn, Leslie W, Pieper, Ursula, Segal, Mark R, Kroetz, Deanna L, Sali, Andrej
Gepubliceerd in 2011

Physiologically‐Based Pharmacokinetic Model‐Informed Drug Development for Fenebrutinib: Understanding Complex Drug‐Drug Interactions

door Chen, Yuan, Ma, Fang, Jones, Nicholas S., Yoshida, Kenta, Chiang, Po‐Chang, Durk, Matthew R., Wright, Matthew R., Jin, Jin Yan, Chinn, Leslie W.
Gepubliceerd in CPT Pharmacometrics Syst Pharmacol (2020)

Understanding the Effect of Hydroxypropyl‐β‐Cyclodextrin on Fenebrutinib Absorption in an Itraconazole–Fenebrutinib Drug–Drug Interaction Study

door Durk, Matthew R., Jones, Nicholas S., Liu, Jia, Nagapudi, Karthik, Mao, Chen, Plise, Emile G., Wong, Susan, Chen, Jacob Z., Chen, Yuan, Chinn, Leslie W., Chiang, Po‐Chang
Gepubliceerd in Clin Pharmacol Ther (2020)

THE HUMAN MULTIDRUG RESISTANCE PROTEIN 4 (MRP4, ABCC4): FUNCTIONAL ANALYSIS OF A HIGHLY POLYMORPHIC GENE

door Abla, Nada, Chinn, Leslie W., Nakamura, Tsutomu, Liu, Li, Huang, Conrad C., Johns, Susan J., Kawamoto, Michiko, Stryke, Doug, Taylor, Travis R., Ferrin, Thomas E., Giacomini, Kathleen M., Kroetz, Deanna L.
Gepubliceerd in 2008

Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans

door Baruch, Amos, Wong, Chin, Chinn, Leslie W., Vaze, Anjali, Sonoda, Junichiro, Gelzleichter, Thomas, Chen, Shan, Lewin-Koh, Nicholas, Morrow, Linda, Dheerendra, Suresh, Boismenu, Richard, Gutierrez, Johnny, Wakshull, Eric, Wilson, Maria E., Arora, Puneet S.
Gepubliceerd in Proc Natl Acad Sci U S A (2020)

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

door Hendrickson, Sher L., Lautenberger, James A., Chinn, Leslie Wei, Malasky, Michael, Sezgin, Efe, Kingsley, Lawrence A., Goedert, James J., Kirk, Gregory D., Gomperts, Edward D., Buchbinder, Susan P., Troyer, Jennifer L., O'Brien, Stephen J.
Gepubliceerd in 2010

Genetic Associations of Variants in Genes Encoding HIV-Dependency Factors Required for HIV-1 Infection

door Chinn, Leslie W., Tang, Minzhong, Kessing, Bailey D., Lautenberger, James A., Troyer, Jennifer L., Malasky, Michael J., McIntosh, Carl, Kirk, Gregory D., Wolinsky, Steven M., Buchbinder, Susan P., Gomperts, Edward D., Goedert, James J., O'Brien, Stephen J.
Gepubliceerd in 2010

Genome-wide Association Study Implicates PARD3B-based AIDS Restriction

door Troyer, Jennifer L., Nelson, George W., Lautenberger, James A., Chinn, Leslie, McIntosh, Carl, Johnson, Randall C., Sezgin, Efe, Kessing, Bailey, Malasky, Michael, Hendrickson, Sher L., Li, Guan, Pontius, Joan, Tang, Minzhong, An, Ping, Winkler, Cheryl A., Limou, Sophie, Le Clerc, Sigrid, Delaneau, Olivier, Zagury, Jean-François, Schuitemaker, Hanneke, van Manen, Daniëlle, Bream, Jay H., Gomperts, Edward D., Buchbinder, Susan, Goedert, James J., Kirk, Gregory D., O'Brien, Stephen J.
Gepubliceerd in 2011

Fenebrutinib Versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double‐Blind, Phase II Trial

door Cohen, Stanley, Tuckwell, Katie, Katsumoto, Tamiko R., Zhao, Rui, Galanter, Joshua, Lee, Chin, Rae, Julie, Toth, Balazs, Ramamoorthi, Nandhini, Hackney, Jason A., Berman, Alberto, Damjanov, Nemanja, Fedkov, Dmytro, Jeka, Slawomir, Chinn, Leslie W., Townsend, Michael J., Morimoto, Alyssa M., Genovese, Mark C., Berman, Alberto, Porto, Alejandro, Granel, Amelia, Asnal, Cecilia, Mysler, Eduardo Fabian, Testa, Gladys Alicia, Zamora, Jose Luis Velasco, Moreno, Jose Luis Cristian, Gulin, Juan Pablo, Hofman, Julio, Ulla, Maria Rosa, Sabelli, Mirtha, Mannucci, Pablo Alejandro, Maid, Pablo Jorge, Melazzi, Ana Cláudia Cauceglia, Scotton, Antônio Scafuto, Ximenes, Antônio Carlos, Funes, Elisete, Gimenez, Emerson Alves, Marcolino, Flora Maria D’Andrea, Neto, João Francisco Marques, Keiserman, Mauro Waldemar, Radominski, Sebastião Cézar, Lima, Sônia Maria Alvarenga Anti Loduca, Pavan, Thaís Rohde, Azevedo, Valderílio Feijó, Koleva, Aneliya, Toncheva, Antoaneta, Bichovska, Daniela, Ivanova, Delina, Penev, Dimitar, Dimitrov, Emil, Mihaylova, Mariyana, Kapandjieva, Nadezhda, Marinova, Natalia, Aleksieva, Tanya, Tsvetanova, Tanya, Petranova, Tsvetanka, Popova, Valentina, Spasov, Yuliy, Toro, Carlos Enrique, Arteaga Unigarro, Carlos Ernesto, Jauregui, Edwin, Hernandez, Javier Dario Marquez, Raad, Juan Jose Jaller, Sanchez, Patricia Julieta Velez, Lee, Chang Keun, Suh, Chang‐Hee, Lee, Eun Young, Lee, Sang‐Heon, Kang, Seong Wook, Lee, Shin‐Seok, Lee, Yun Jong, Montiel, Beatriz Elena Zazueta, Pinzon de la O, Blanca Irma, Friedmann, Daniel Xibille, Lopez, Francisco Rosas, Torres, Isaura Rodriguez, Quezada, Luis Jara, Ceceña, Marco Maradiaga, Hernandez, Miguel Cortes, Salinas, Miguel Saavedra, Rapa, Agnieszka, Pawtel, Agnieszka, Zielinska, Agnieszka, Dudek, Anna, Rychlewska‐Hanczewska, Anna, Strzelecka, Anna, Racewicz, Artur, Stasiuk, Barbara, Gruszecka, Katarzyna, Dworak, Krystyna, Jeka, Slawomir, Lowenhoff, Tomasz, Maslyanskiy, Alexey, Rebrov, Andrey, Krechikova, Diana, Zhugrova, Elena, Shmidt, Evgeniya, Matsievskaya, Galina, Vinogradova, Irina, Ler, Irina, Eliseeva, Larisa, Savina, Ludmila, Stanislav, Marina, Sandin, Mikhail, Zyablova, Natalia, Korshunov, Nikolay, Mosesova, Nino, Polovnikova, Oksana, Nesmeyanova, Olga, Samigullina, Ruzana, Moiseev, Sergey, Noskov, Sergey, Raskina, Tatiana, Popova, Tatiana, Marchenko, Valeriy, Jovanovski, Aleksandar, Stamenkovic, Bojana, Ristic, Gorica, Lazarevic, Milijanka, Veselinovic, Mirjana, Vujasinovic‐Stupar, Nada, Damjanov, Nemanja, Ostojic, Predrag, Yagensky, Andriy, Gnylorybov, Andriy, Rekalov, Dmytro, Reshotko, Dmytroo, Fedkov, Dmytro, Dzyak, Georgiy, Gasanov, Iurii, Khimion, Ludmila, Stanislavchuk, Mykola, Prykhodko, Natalya, Nadashkevych, Oleg, Bortkevych, Oleg, Abrahamovych, Orest, Yatsyshyn, Roman, Turyanytsya, Samvel, Smiyan, Svitlana, Vizir, Vadym, Kachur, Victoria, Tseluyko, Vira, Povoroznyuk, Vladyslav, Koshlia, Volodymyr, Zhdan, Vyacheslav, Lymar, Yurii, Mostovoy, Yuriy, Hawkes, Angela, Mabaquiao, Arthur, Chu, Cong‐Qiu, Scoville, Craig, Wyatt, David, Weinstein, Debra, McIlwain, Harris, Vo, Jacqueline, Poiley, Jeffrey, Forstot, Joseph, Dao, Kathryn, Turner, Mark, Genovese, Mark, Borofsky, Michael, Caldron, Paul, Waller, Philip, Levin, Robert, Metyas, Samy, Stein, Scott, Shroff, Sharukh, Pang, Shirley, Cohen, Stanley, Syed, Tauseef, Chindalore, Vishala
Gepubliceerd in Arthritis Rheumatol (2020)