Understanding the Effect of Hydroxypropyl‐β‐Cyclodextrin on Fenebrutinib Absorption in an Itraconazole–Fenebrutinib Drug–Drug Interaction Study

Cyclodextrins are widely used pharmaceutical excipients, particularly for insoluble compounds dosed orally, such as the oral solution of itraconazole, which is frequently used in clinical drug–drug interaction studies to inhibit cytochrome P450 3A. Since cyclodextrins act by forming inclusion comple...

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Bibliographic Details
Published in:Clin Pharmacol Ther
Main Authors: Durk, Matthew R., Jones, Nicholas S., Liu, Jia, Nagapudi, Karthik, Mao, Chen, Plise, Emile G., Wong, Susan, Chen, Jacob Z., Chen, Yuan, Chinn, Leslie W., Chiang, Po‐Chang
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689742/
https://ncbi.nlm.nih.gov/pubmed/32535897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1943
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