Structural Variants in SNCA Gene and the Implication to Synucleinopathies

por Chiba-Falek, Ornit
Publicado no Curr Opin Genet Dev (2017)

Towards precision medicine in Alzheimer’s disease: deciphering genetic data to establish informative biomarkers

por Chiba-Falek, Ornit, Lutz, Michael W.
Publicado no Expert Rev Precis Med Drug Dev (2017)

Probing the role of PPARγ in the regulation of late-onset Alzheimer’s disease-associated genes

por Barrera, Julio, Subramanian, Shobana, Chiba-Falek, Ornit
Publicado no PLoS One (2018)

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders

por Gamache, Julia, Yun, Young, Chiba-Falek, Ornit
Publicado no Dis Model Mech (2020)

APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer’s

por Yang, Anna, Kantor, Boris, Chiba-Falek, Ornit
Publicado no Int J Mol Sci (2021)

Multiplication of the SNCA locus exacerbates neuronal nuclear aging

por Tagliafierro, Lidia, Zamora, Madison Elena, Chiba-Falek, Ornit
Publicado no Hum Mol Genet (2019)

Bioinformatics strategy to advance the interpretation of Alzheimer’s disease GWAS discoveries: the roads from association to causation

por Lutz, Michael W., Sprague, Daniel, Chiba-Falek, Ornit
Publicado no Alzheimers Dement (2019)

The effects of the TOMM40 poly-T alleles on Alzheimer’s disease phenotypes

por Chiba-Falek, Ornit, Gottschalk, William K., Lutz, Michael W.
Publicado no Alzheimers Dement (2018)

Good problems to have? Policy and societal implications of a disease-modifying therapy for presymptomatic late-onset Alzheimer’s disease

por Angrist, Misha, Yang, Anna, Kantor, Boris, Chiba-Falek, Ornit
Publicado no Life Sci Soc Policy (2020)

Gene Expression Analysis of Neurons and Astrocytes Isolated by Laser Capture Microdissection from Frozen Human Brain Tissues

por Tagliafierro, Lidia, Bonawitz, Kirsten, Glenn, Omolara C., Chiba-Falek, Ornit
Publicado no Front Mol Neurosci (2016)

Shared genetic etiology underlying Alzheimer’s disease and major depressive disorder

por Lutz, Michael W., Sprague, Daniel, Barrera, Julio, Chiba-Falek, Ornit
Publicado no Transl Psychiatry (2020)

Gene-Editing Technologies Paired With Viral Vectors for Translational Research Into Neurodegenerative Diseases

por Rittiner, Joseph Edward, Moncalvo, Malik, Chiba-Falek, Ornit, Kantor, Boris
Publicado no Front Mol Neurosci (2020)

The Role of Upregulated APOE in Alzheimer’s Disease Etiology

por Gottschalk, William K, Mihovilovic, Mirta, Roses, Allen D, Chiba-Falek, Ornit
Publicado no J Alzheimers Dis Parkinsonism (2016)

Shared Genetic Etiology Underlying Late-Onset Alzheimer’s Disease and Post Traumatic Stress Syndrome

por Lutz, Michael W., Luo, Sheng, Williamson, Douglas E., Chiba-Falek, Ornit
Publicado no Alzheimers Dement (2020)

The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models

por MacDougall, Gabriella, Brown, Logan Y., Kantor, Boris, Chiba-Falek, Ornit
Publicado no Mol Ther (2021)

Regulation of α-Synuclein Expression by Poly (ADP Ribose) Polymerase-1 (PARP-1) Binding to the NACP-Rep1 Polymorphic Site Upstream of the SNCA Gene

por Chiba-Falek, Ornit, Kowalak, Jeffrey A., Smulson, Mark E., Nussbaum, Robert L.
Publicado em 2005

The SSV evaluation system: a tool to prioritize short structural variants for studies of possible regulatory and causal variants

por Saul, Robert, Lutz, Michael W., Burns, Daniel K., Roses, Allen D., Chiba-Falek, Ornit
Publicado no Hum Mutat (2016)

The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster

por Subramanian, Shobana, Gottschalk, William K., Kim, So Young, Roses, Allen D., Chiba-Falek, Ornit
Publicado no Biochim Biophys Acta (2017)

Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from SNCA rs356168

por Glenn, Omolara-Chinue, Tagliafierro, Lidia, Beach, Thomas G., Woltjer, Randy L., Chiba-Falek, Ornit
Publicado no Front Genet (2017)

A CT-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer’s disease and affects SNCA expression

por Lutz, Michael W., Saul, Robert, Linnertz, Colton, Glenn, Omolara-Chinue, Roses, Allen D., Chiba-Falek, Ornit
Publicado no Alzheimers Dement (2015)