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Bioinformatics strategy to advance the interpretation of Alzheimer’s disease GWAS discoveries: the roads from association to causation

INTRODUCTION: Genome-wide-association studies (GWAS) discovered multiple late-onset Alzheimer’s disease (LOAD)-associated SNPs and inferred the genes based on proximity, however, the actual causal genes are yet to be identified. METHODS: We defined LOAD-GWAS regions by the most significantly associa...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement
Main Authors: Lutz, Michael W., Sprague, Daniel, Chiba-Falek, Ornit
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699885/
https://ncbi.nlm.nih.gov/pubmed/31262699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2019.04.014
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