Agonist efficacy and receptor desensitization: from partial truths to a fuller picture

por Charlton, Steven J
Publicado 2009

Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action

por Vauquelin, Georges, Charlton, Steven J
Publicado 2010

Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays

por Charlton, Steven J, Vauquelin, Georges
Publicado 2010

Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

por Vauquelin, Georges, Charlton, Steven J
Publicado 2013

Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M(3) receptor

por Dowling, Mark R, Charlton, Steven J
Publicado 2006

BJP issue on drug discovery

por Charlton, Steven J, Bond, Richard A
Publicado 2010

Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β(2)-adrenoceptor agonists

por Sykes, David A, Charlton, Steven J
Publicado 2012

Airway remodeling disease: primary human structural cells and phenotypic and pathway assays to identify targets with potential to prevent or reverse remodeling

por Rosethorne, Elizabeth M, Charlton, Steven J
Publicado en J Exp Pharmacol (2018)

‘Partial’ competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models

por Vauquelin, Georges, Hall, David, Charlton, Steven J
Publicado en Br J Pharmacol (2015)

Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes

por Gherbi, Karolina, Briddon, Stephen J., Charlton, Steven J.
Publicado en Sci Rep (2018)

Enhancement of the response to purinergic agonists in P2Y(1) transfected 1321N1 cells by antagonists suramin and PPADS

por Brown, Colin A, Charlton, Steven J, Boarder, Michael R
Publicado 1997

The long-acting β-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells

por Scola, Anne-Marie, Loxham, Matthew, Charlton, Steven J, Peachell, Peter T
Publicado 2009

Functional desensitization of the β(2) adrenoceptor is not dependent on agonist efficacy

por Rosethorne, Elizabeth M, Bradley, Michelle E, Kent, Toby C, Charlton, Steven J
Publicado en Pharmacol Res Perspect (2015)

Evidence that P2Y(4) nucleotide receptors are involved in the regulation of rat aortic smooth muscle cells by UTP and ATP

por Harper, Simon, Webb, Tania E, Charlton, Steven J, Ng, Leong L, Boarder, Michael R
Publicado 1998

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response

por Roberts, Maxine J., Broome, Rebecca E., Kent, Toby C., Charlton, Steven J., Rosethorne, Elizabeth M.
Publicado en Respir Res (2018)

Reply to ‘Antipsychotics with similar association kinetics at dopamine D(2) receptors differ in extrapyramidal side-effects’

por Sykes, David A., Lane, J. Robert, Szabo, Monika, Capuano, Ben, Javitch, Jonathan A., Charlton, Steven J.
Publicado en Nat Commun (2018)

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D(2) receptors

por Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert, Charlton, Steven J.
Publicado en Nat Commun (2017)

The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease()

por Dale, Philippa R, Cernecka, Hana, Schmidt, Martina, Dowling, Mark R, Charlton, Steven J, Pieper, Michael P, Michel, Martin C
Publicado 2014

Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

por Roberts, Maxine J., May, Lauren T., Keen, Alastair C., Liu, Bonan, Lam, Terrance, Charlton, Steven J., Rosethorne, Elizabeth M., Halls, Michelle L.
Publicado en Front Pharmacol (2021)

Pre-assembled GPCR signaling complexes mediate unique cellular responses to ultra-low ligand concentrations

por Civciristov, Srgjan, Ellisdon, Andrew M., Suderman, Ryan, Pon, Cindy K., Evans, Bronwyn A., Kleifeld, Oded, Charlton, Steven J., Hlavacek, William S., Canals, Meritxell, Halls, Michelle L.
Publicado en Sci Signal (2018)