Emerging paradigm of intracellular targeting of GPCRs

by Chaturvedi, Madhu, Schilling, Justin, Beautrait, Alexandre, Bouvier, Michel, Benovic, Jeffrey L., Shukla, Arun K.
Published in Trends Biochem Sci (2018)

Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay

by Normandin, Karine, Lavallée, Jean-François, Futter, Marie, Beautrait, Alexandre, Duchaine, Jean, Guiral, Sébastien, Marinier, Anne, Archambault, Vincent
Published in Sci Rep (2016)

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

by Paradis, Justine S., Ly, Stevenson, Blondel-Tepaz, Élodie, Galan, Jacob A., Beautrait, Alexandre, Scott, Mark G. H., Enslen, Hervé, Marullo, Stefano, Roux, Philippe P., Bouvier, Michel
Published in Proc Natl Acad Sci U S A (2015)

Identification of Allosteric Inhibitors against Active Caspase-6

by Tubeleviciute-Aydin, Agne, Beautrait, Alexandre, Lynham, Jeffrey, Sharma, Gyanesh, Gorelik, Alexei, Deny, Ludovic J., Soya, Naoto, Lukacs, Gergely L., Nagar, Bhushan, Marinier, Anne, LeBlanc, Andrea C.
Published in Sci Rep (2019)

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS

by Beautrait, Alexandre, Michalski, Kevin R., Lopez, Thomas S., Mannix, Katelynn M., McDonald, Devin J., Cutter, Amber R., Medina, Christopher B., Hebert, Aaron M., Francis, Charnelle J., Bouvier, Michel, Tesmer, John J. G., Sterne-Marr, Rachel
Published 2014

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

by Beautrait, Alexandre, Paradis, Justine S., Zimmerman, Brandon, Giubilaro, Jenna, Nikolajev, Ljiljana, Armando, Sylvain, Kobayashi, Hiroyuki, Yamani, Lama, Namkung, Yoon, Heydenreich, Franziska M., Khoury, Etienne, Audet, Martin, Roux, Philippe P., Veprintsev, Dmitry B., Laporte, Stéphane A., Bouvier, Michel
Published in Nat Commun (2017)