Emerging paradigm of intracellular targeting of GPCRs

door Chaturvedi, Madhu, Schilling, Justin, Beautrait, Alexandre, Bouvier, Michel, Benovic, Jeffrey L., Shukla, Arun K.
Gepubliceerd in Trends Biochem Sci (2018)

Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay

door Normandin, Karine, Lavallée, Jean-François, Futter, Marie, Beautrait, Alexandre, Duchaine, Jean, Guiral, Sébastien, Marinier, Anne, Archambault, Vincent
Gepubliceerd in Sci Rep (2016)

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

door Paradis, Justine S., Ly, Stevenson, Blondel-Tepaz, Élodie, Galan, Jacob A., Beautrait, Alexandre, Scott, Mark G. H., Enslen, Hervé, Marullo, Stefano, Roux, Philippe P., Bouvier, Michel
Gepubliceerd in Proc Natl Acad Sci U S A (2015)

Identification of Allosteric Inhibitors against Active Caspase-6

door Tubeleviciute-Aydin, Agne, Beautrait, Alexandre, Lynham, Jeffrey, Sharma, Gyanesh, Gorelik, Alexei, Deny, Ludovic J., Soya, Naoto, Lukacs, Gergely L., Nagar, Bhushan, Marinier, Anne, LeBlanc, Andrea C.
Gepubliceerd in Sci Rep (2019)

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS

door Beautrait, Alexandre, Michalski, Kevin R., Lopez, Thomas S., Mannix, Katelynn M., McDonald, Devin J., Cutter, Amber R., Medina, Christopher B., Hebert, Aaron M., Francis, Charnelle J., Bouvier, Michel, Tesmer, John J. G., Sterne-Marr, Rachel
Gepubliceerd in 2014

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

door Beautrait, Alexandre, Paradis, Justine S., Zimmerman, Brandon, Giubilaro, Jenna, Nikolajev, Ljiljana, Armando, Sylvain, Kobayashi, Hiroyuki, Yamani, Lama, Namkung, Yoon, Heydenreich, Franziska M., Khoury, Etienne, Audet, Martin, Roux, Philippe P., Veprintsev, Dmitry B., Laporte, Stéphane A., Bouvier, Michel
Gepubliceerd in Nat Commun (2017)