A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

In addition to G protein-coupled receptor (GPCR) desensitization and endocytosis, β-arrestin recruitment to ligand-stimulated GPCRs promotes non-canonical signalling cascades. Distinguishing the respective contributions of β-arrestin recruitment to the receptor and β-arrestin-promoted endocytosis in...

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Publicado no:Nat Commun
Main Authors: Beautrait, Alexandre, Paradis, Justine S., Zimmerman, Brandon, Giubilaro, Jenna, Nikolajev, Ljiljana, Armando, Sylvain, Kobayashi, Hiroyuki, Yamani, Lama, Namkung, Yoon, Heydenreich, Franziska M., Khoury, Etienne, Audet, Martin, Roux, Philippe P., Veprintsev, Dmitry B., Laporte, Stéphane A., Bouvier, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399295/
https://ncbi.nlm.nih.gov/pubmed/28416805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15054
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