A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

In addition to G protein-coupled receptor (GPCR) desensitization and endocytosis, β-arrestin recruitment to ligand-stimulated GPCRs promotes non-canonical signalling cascades. Distinguishing the respective contributions of β-arrestin recruitment to the receptor and β-arrestin-promoted endocytosis in...

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Pubblicato in:Nat Commun
Autori principali: Beautrait, Alexandre, Paradis, Justine S., Zimmerman, Brandon, Giubilaro, Jenna, Nikolajev, Ljiljana, Armando, Sylvain, Kobayashi, Hiroyuki, Yamani, Lama, Namkung, Yoon, Heydenreich, Franziska M., Khoury, Etienne, Audet, Martin, Roux, Philippe P., Veprintsev, Dmitry B., Laporte, Stéphane A., Bouvier, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399295/
https://ncbi.nlm.nih.gov/pubmed/28416805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15054
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