Effects of a Fluorescent Myosin Light Chain Phosphatase Inhibitor on Prostate Cancer Cells

Por Grindrod, Scott, Suy, Simeng, Fallen, Shannon, Eto, Masumi, Toretsky, Jeffrey, Brown, Milton L.
Publicado em 2011

Discovery of Diphenyl Amine Based Sodium Channel Blockers, Effective Against hNa(v)1.2

Por Hudgens, Debjani P., Taylor, Catherine, Batts, Timothy W., Patel, Manoj K., Brown, Milton L.
Publicado em 2006

Comparative Molecular Field Analysis and Synthetic Validation of a Hydroxyamide-Propofol Binding and Functional Block of Neuronal Voltage-Dependent Sodium Channels

Por Brown, Milton L., Eidam, Hilary A., Paige, Mikell, Jones, Paulianda J., Patel, Manoj K.
Publicado em 2008

YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion

Por Rahim, Said, Beauchamp, Elspeth M., Kong, Yali, Brown, Milton L., Toretsky, Jeffrey A., Üren, Aykut
Publicado em 2011

Mechanistic Exploration of Phthalimide Neovascular Factor 1 Using Network Analysis Tools

Por WIEGHAUS, KRISTEN A., GIANCHANDANI, ERWIN P., BROWN, MILTON L., PAPIN, JASON A., BOTCHWEY, EDWARD A.
Publicado em 2007

Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin–lidocaine pharmacophore

Por Wang, Yuesheng, Jones, Paulianda J., Batts, Timothy W., Landry, Victoria, Patel, Manoj K., Brown, Milton L.
Publicado em 2008

Trans-resveratrol boronic acid exhibits enhanced anti-proliferative activity on estrogen-dependent MCF-7 breast cancer cells

Por Yenugonda, Venkata Mahidhar, Kong, Yali, Deb, Tushar B., Yang, Yonghong, Riggins, Rebecca B., Brown, Milton L.
Publicado em 2012

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells

Por Yi, Yong Weon, Kang, Hyo Jin, Kim, Hee Jeong, Kong, Yali, Brown, Milton L., Bae, Insoo
Publicado em 2013

BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant hu...

Por Nathan, Shyam, Ma, Yongxian, Tomita, York A., De Oliveira, Eliseu, Brown, Milton L., Rosen, Eliot M.
Publicado no Breast Cancer Res Treat (2017)

Asymmetric Synthesis of 2,3-Dihydro-2-arylquinazolin-4-ones: Methodology and Application to a Potent Fluorescent Tubulin Inhibitor with Anticancer Activity

Por Chinigo, Gary M., Paige, Mikell, Grindrod, Scott, Hamel, Ernest, Dakshanamurthy, Sivanesan, Chruszcz, Maksymilian, Minor, Wladek, Brown, Milton L.
Publicado em 2008

Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule

Por Wieghaus, Kristen A., Gianchandani, Erwin P., Paige, Mikell A., Brown, Milton L., Botchwey, Edward A., Papin, Jason A.
Publicado em 2008

A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent

Por Kong, Yali, Wang, Kan, Edler, Michael C., Hamel, Ernest, Mooberry, Susan L., Paige, Mikell A., Brown, Milton L.
Publicado em 2009

Preclinical Studies of YK-4-272, an Inhibitor of Class II Histone Deacetylases by Disruption of Nucleocytoplasmic Shuttling

Por Kong, Hye-Sik, Tian, Shuo, Kong, Yali, Du, Guanhua, Zhang, Li, Jung, Mira, Dritschilo, Anatoly, Brown, Milton L.
Publicado em 2012

Design, Synthesis and Biological Evaluation of Ezrin Inhibitors Targeting Metastatic Osteosarcoma

Por Paige, Mikell, Kosturko, George, Bulut, Gullay, Miessau, Matthew, Rahim, Said, Toretsky, Jeffrey A., Brown, Milton L., Üren, Aykut
Publicado no Bioorg Med Chem (2013)

Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor

Por Kang, Hyo Jin, Yi, Yong Weon, Hou, Shu-Jie, Kim, Hee Jeong, Kong, Yali, Bae, Insoo, Brown, Milton L.
Publicado no Oncotarget (2015)

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

Por Timofeeva, Olga A., Tarasova, Nadya I., Zhang, Xueping, Chasovskikh, Sergey, Cheema, Amrita K., Wang, Honghe, Brown, Milton L., Dritschilo, Anatoly
Publicado em 2013

Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells

Por Wieghaus, Kristen A., Gianchandani, Erwin P., Neal, Rebekah A., Paige, Mikell A., Brown, Milton L., Papin, Jason A., Botchwey, Edward A.
Publicado em 2009

Predicting New Indications for Approved Drugs Using a Proteo-Chemometric Method

Por Dakshanamurthy, Sivanesan, Issa, Naiem T, Assefnia, Shahin, Seshasayee, Ashwini, Peters, Oakland J, Madhavan, Subha, Uren, Aykut, Brown, Milton L, Byers, Stephen W
Publicado em 2012

DIM (3,3′-diindolylmethane) confers protection against ionizing radiation by a unique mechanism

Por Fan, Saijun, Meng, Qinghui, Xu, Jiaying, Jiao, Yang, Zhao, Lin, Zhang, Xiaodong, Sarkar, Fazlul H., Brown, Milton L., Dritschilo, Anatoly, Rosen, Eliot M.
Publicado em 2013

Small-Molecule “BRCA1-Mimetics” Are Antagonists of Estrogen Receptor-α

Por Ma, Yongxian, Tomita, York, Preet, Anju, Clarke, Robert, Englund, Erikah, Grindrod, Scott, Nathan, Shyam, De Oliveira, Eliseu, Brown, Milton L., Rosen, Eliot M.
Publicado no Mol Endocrinol (2014)