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STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. In the characterization of effects of ST3-H2A2, a selective inhibitor of the STAT3 N-terminal domain (ND), we observed that the co...

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Bibliografiske detaljer
Main Authors: Timofeeva, Olga A., Tarasova, Nadya I., Zhang, Xueping, Chasovskikh, Sergey, Cheema, Amrita K., Wang, Honghe, Brown, Milton L., Dritschilo, Anatoly
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557078/
https://ncbi.nlm.nih.gov/pubmed/23288901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211805110
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