STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. In the characterization of effects of ST3-H2A2, a selective inhibitor of the STAT3 N-terminal domain (ND), we observed that the co...

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Autori principali: Timofeeva, Olga A., Tarasova, Nadya I., Zhang, Xueping, Chasovskikh, Sergey, Cheema, Amrita K., Wang, Honghe, Brown, Milton L., Dritschilo, Anatoly
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557078/
https://ncbi.nlm.nih.gov/pubmed/23288901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211805110
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