Nuclear Tau and Its Potential Role in Alzheimer’s Disease

gan Bukar Maina, Mahmoud, Al-Hilaly, Youssra K., Serpell, Louise C.
Cyhoeddwyd yn Biomolecules (2016)

Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

gan Maina, Mahmoud B., Burra, Gunasekhar, Al-Hilaly, Youssra K., Mengham, Kurtis, Fennell, Kate, Serpell, Louise C.
Cyhoeddwyd yn iScience (2020)

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

gan Raulin, Ana-Caroline, Kraft, Lucas, Al-Hilaly, Youssra K., Xue, Wei-Feng, McGeehan, John E., Atack, John R., Serpell, Louise
Cyhoeddwyd yn J Mol Biol (2019)

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target

gan Oakley, Sebastian S., Maina, Mahmoud B., Marshall, Karen E., Al-Hilaly, Youssra K., Harrington, Charlie R., Wischik, Claude M., Serpell, Louise C.
Cyhoeddwyd yn Front Neurol (2020)

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

gan Maina, Mahmoud B., Al-Hilaly, Youssra K., Burra, Gunasekhar, Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Cyhoeddwyd yn Cells (2021)

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease

gan Al-Hilaly, Youssra K., Biasetti, Luca, Blakeman, Ben J. F., Pollack, Saskia J., Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R., Xue, Wei-Feng, Serpell, Louise C.
Cyhoeddwyd yn Sci Rep (2016)

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

gan Marshall, Karen E., Vadukul, Devkee M., Dahal, Liza, Theisen, Alina, Fowler, Milena W., Al-Hilaly, Youssra, Ford, Lenzie, Kemenes, György, Day, Iain J., Staras, Kevin, Serpell, Louise C.
Cyhoeddwyd yn Sci Rep (2016)

Paired Helical Filament-Forming Region of Tau (297–391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells

gan Pollack, Saskia J., Trigg, Jasmine, Khanom, Tahmida, Biasetti, Luca, Marshall, Karen E., Al-Hilaly, Youssra K., Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Cyhoeddwyd yn J Mol Biol (2020)

Using chirality to influence supramolecular gelation

gan McAulay, Kate, Dietrich, Bart, Su, Hao, Scott, Michael T., Rogers, Sarah, Al-Hilaly, Youssra K., Cui, Honggang, Serpell, Louise C., Seddon, Annela M., Draper, Emily R., Adams, Dave J.
Cyhoeddwyd yn Chem Sci (2019)

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

gan Al-Hilaly, Youssra K, Williams, Thomas L, Stewart-Parker, Maris, Ford, Lenzie, Skaria, Eldhose, Cole, Michael, Bucher, William Grant, Morris, Kyle L, Sada, Alaa Abdul, Thorpe, Julian R, Serpell, Louise C
Cyhoeddwyd 2013

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

gan Al‐Hilaly, Youssra K., Foster, Bronwen E., Biasetti, Luca, Lutter, Liisa, Pollack, Saskia J., Rickard, Janet E., Storey, John M. D., Harrington, Charles R., Xue, Wei‐Feng, Wischik, Claude M., Serpell, Louise C.
Cyhoeddwyd yn FEBS Lett (2019)

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

gan Fichou, Yann, Al-Hilaly, Youssra K., Devred, François, Smet-Nocca, Caroline, Tsvetkov, Philipp O., Verelst, Joke, Winderickx, Joris, Geukens, Nick, Vanmechelen, Eugeen, Perrotin, Audrey, Serpell, Louise, Hanseeuw, Bernard J, Medina, Miguel, Buée, Luc, Landrieu, Isabelle
Cyhoeddwyd yn Acta Neuropathol Commun (2019)

The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation

gan Ruiz-Zamora, Robin Axel, Guillaumé, Simon, Al-Hilaly, Youssra K., Al-Garawi, Zahraa, Rodríguez-Alvarez, Francisco Javier, Zavala-Padilla, Guadalupe, Pérez-Carreón, Julio I., Rodríguez-Ambriz, Sandra L., Herrera, Guillermo A., Becerril-Luján, Baltazar, Ochoa-Leyva, Adrián, Melendez-Zajgla, Jorge, Serpell, Louise, del Pozo-Yauner, Luis
Cyhoeddwyd yn Sci Rep (2019)