Corruption of Innate Immunity by Bacterial Proteases

Por Potempa, Jan, Pike, Robert N.
Publicado em 2009

Molecular characterization of centerin, a germinal centre cell serpin

Por Paterson, Melinda A., Horvath, Anita J., Pike, Robert N., Coughlin, Paul B.
Publicado em 2007

The anticoagulant activation of antithrombin by heparin

Por Jin, Lei, Abrahams, Jan Pieter, Skinner, Richard, Petitou, Maurice, Pike, Robert N., Carrell, Robin W.
Publicado em 1997

The Role of Protease-Activated Receptor-1 in Bone Healing

Por Song, Shu Jun, Pagel, Charles N., Campbell, Therese M., Pike, Robert N., Mackie, Eleanor J.
Publicado em 2005

The role of strand 1 of the C β-sheet in the structure and function of α(1)-antitrypsin

Por Bottomley, Stephen P., Lawrenson, Isobel D., Tew, Deborah, Dai, Weiwen, Whisstock, James C., Pike, Robert N.
Publicado em 2001

PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites

Por Song, Jiangning, Tan, Hao, Perry, Andrew J., Akutsu, Tatsuya, Webb, Geoffrey I., Whisstock, James C., Pike, Robert N.
Publicado em 2012

Scabies Mite Inactive Serine Proteases Are Potent Inhibitors of the Human Complement Lectin Pathway

Por Reynolds, Simone L., Pike, Robert N., Mika, Angela, Blom, Anna M., Hofmann, Andreas, Wijeyewickrema, Lakshmi C., Kemp, Dave, Fischer, Katja
Publicado em 2014

The protease cathepsin L regulates Th17 cell differentiation

Por Hou, Lifei, Cooley, Jessica, Swanson, Richard, Ong, Poh Chee, Pike, Robert N., Bogyo, Matthew, Olson, Steven T., Remold-O’Donnell, Eileen
Publicado no J Autoimmun (2015)

Arginine-Specific Protease from Porphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion

Por Lourbakos, Afrodite, Potempa, Jan, Travis, James, D'Andrea, Michael R., Andrade-Gordon, Patricia, Santulli, Rosemary, Mackie, Eleanor J., Pike, Robert N.
Publicado em 2001

Protease-associated import systems are widespread in Gram-negative bacteria

Por Grinter, Rhys, Leung, Pok Man, Wijeyewickrema, Lakshmi C., Littler, Dene, Beckham, Simone, Pike, Robert N., Walker, Daniel, Greening, Chris, Lithgow, Trevor
Publicado no PLoS Genet (2019)

High Molecular Weight Gingipains from Porphyromonas gingivalis Induce Cytokine Responses from Human Macrophage-Like Cells via a Nonproteolytic Mechanism

Por Fitzpatrick, Rebecca E., Aprico, Andrea, Wijeyewickrema, Lakshmi C., Pagel, Charles N., Wong, David M., Potempa, Jan, Mackie, Eleanor J., Pike, Robert N.
Publicado em 2009

PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy

Por Song, Jiangning, Li, Fuyi, Leier, André, Marquez-Lago, Tatiana T, Akutsu, Tatsuya, Haffari, Gholamreza, Chou, Kuo-Chen, Webb, Geoffrey I, Pike, Robert N
Publicado no Bioinformatics (2018)

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, M...

Por Yongqing, Tang, Wilmann, Pascal G., Reeve, Shane B., Coetzer, Theresa H., Smith, A. Ian, Whisstock, James C., Pike, Robert N., Wijeyewickrema, Lakshmi C.
Publicado em 2013

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, M...

Por Yongqing, Tang, Wilmann, Pascal G., Reeve, Shane B., Coetzer, Theresa H., Smith, A. Ian, Whisstock, James C., Pike, Robert N., Wijeyewickrema, Lakshmi C.
Publicado em 2013

Cloning and Expression of the Major Secreted Cathepsin B-Like Protein from Juvenile Fasciola hepatica and Analysis of Immunogenicity following Liver Fluke Infection

Por Law, Ruby H. P., Smooker, Peter M., Irving, James A., Piedrafita, David, Ponting, Rebecca, Kennedy, Nicholas J., Whisstock, James C., Pike, Robert N., Spithill, Terry W.
Publicado em 2003

Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r

Por Wijeyewickrema, Lakshmi C., Yongqing, Tang, Tran, Thuy P., Thompson, Phillip E., Viljoen, Jacqueline E., Coetzer, Theresa H., Duncan, Renee C., Kass, Itamar, Buckle, Ashley M., Pike, Robert N.
Publicado em 2013

Protease-Activated Receptor 2 Has Pivotal Roles in Cellular Mechanisms Involved in Experimental Periodontitis

Por Wong, David M., Tam, Vivian, Lam, Roselind, Walsh, Katrina A., Tatarczuch, Liliana, Pagel, Charles N., Reynolds, Eric C., O'Brien-Simpson, Neil M., Mackie, Eleanor J., Pike, Robert N.
Publicado em 2010

Molecular basis for the folding of β-helical autotransporter passenger domains

Por Yuan, Xiaojun, Johnson, Matthew D., Zhang, Jing, Lo, Alvin W., Schembri, Mark A., Wijeyewickrema, Lakshmi C., Pike, Robert N., Huysmans, Gerard H. M., Henderson, Ian R., Leyton, Denisse L.
Publicado no Nat Commun (2018)

Characterization of a Serine Protease Homologous to House Dust Mite Group 3 Allergens from the Scabies Mite Sarcoptes scabiei

Por Beckham, Simone A., Boyd, Sarah E., Reynolds, Simone, Willis, Charlene, Johnstone, Masego, Mika, Angela, Simerská, Pavla, Wijeyewickrema, Lakshmi C., Smith, A. Ian, Kemp, David J., Pike, Robert N., Fischer, Katja
Publicado em 2009

S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction

Por Wong, Wilson, Wijeyewickrema, Lakshmi C., Kennan, Ruth M., Reeve, Shane B., Steer, David L., Reboul, Cyril, Smith, A. Ian, Pike, Robert N., Rood, Julian I., Whisstock, James C., Porter, Corrine J.
Publicado em 2011