The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome

The mannose-binding lectin associated-protease-3 (MASP-3) is a member of the lectin pathway of the complement system, a key component of human innate and active immunity. Mutations in MASP-3 have recently been found to be associated with Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome, a...

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Detalhes bibliográficos
Main Authors: Yongqing, Tang, Wilmann, Pascal G., Reeve, Shane B., Coetzer, Theresa H., Smith, A. Ian, Whisstock, James C., Pike, Robert N., Wijeyewickrema, Lakshmi C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829330/
https://ncbi.nlm.nih.gov/pubmed/23792966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.483875
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