Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r

The serine protease, C1r, initiates activation of the classical pathway of complement, which is a crucial innate defense mechanism against pathogens and altered-self cells. C1r both autoactivates and subsequently cleaves and activates C1s. Because complement is implicated in many inflammatory diseas...

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Main Authors: Wijeyewickrema, Lakshmi C., Yongqing, Tang, Tran, Thuy P., Thompson, Phillip E., Viljoen, Jacqueline E., Coetzer, Theresa H., Duncan, Renee C., Kass, Itamar, Buckle, Ashley M., Pike, Robert N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668718/
https://ncbi.nlm.nih.gov/pubmed/23589288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451757
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