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A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4
The complement system is an ancient innate immune defense pathway that plays a front line role in eliminating microbial pathogens. Recognition of foreign targets by antibodies drives sequential activation of two serine proteases, C1r and C1s, which reside within the complement Component 1 (C1) compl...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3668739/ https://ncbi.nlm.nih.gov/pubmed/23592783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464545 |
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