NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses

Por Kounnas, Maria Z., Durakoglugil, Murat S., Herz, Joachim, Comer, William T.
Publicado no Alzheimers Dement (N Y) (2019)

NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ(42,) in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents

Por Kounnas, Maria Z., Lane-Donovan, Courtney, Nowakowski, Dan W., Herz, Joachim, Comer, William T.
Publicado no Alzheimers Dement (N Y) (2016)

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

Por Varvel, Nicholas H., Bhaskar, Kiran, Kounnas, Maria Z., Wagner, Steven L., Yang, Yan, Lamb, Bruce T., Herrup, Karl
Publicado em 2009

Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes

Por Calvier, Laurent, Xian, Xunde, Lee, Richard, Sacharidou, Anastasia, Mineo, Chieko, Shaul, Philip W., Kounnas, Maria Z, Tsai, Shirling, Herz, Joachim
Publicado no Arterioscler Thromb Vasc Biol (2021)

Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates

Por Gong, Ping, Vetrivel, Kulandaivelu S., Nguyen, Phuong D., Meckler, Xavier, Cheng, Haipeng, Kounnas, Maria Z., Wagner, Steven L., Parent, Angèle T., Thinakaran, Gopal
Publicado em 2010

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines

Por Pontecorvi, Paola, Banki, Michael A., Zampieri, Carlotta, Zalfa, Cristina, Azmoon, Pardis, Kounnas, Maria Z., Marchese, Cinzia, Gonias, Steven L., Mantuano, Elisabetta
Publicado no J Neuroinflammation (2019)

Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

Por Vetrivel, Kulandaivelu S., Meckler, Xavier, Chen, Ying, Nguyen, Phuong D., Seidah, Nabil G., Vassar, Robert, Wong, Philip C., Fukata, Masaki, Kounnas, Maria Z., Thinakaran, Gopal
Publicado em 2009

Reelin Depletion Protects Against Autoimmune Encephalomyelitis by Decreasing Vascular Adhesion of Leukocytes

Por Calvier, Laurent, Demuth, Guillaume, Manouchehri, Navid, Wong, Connie, Sacharidou, Anastasia, Mineo, Chieko, Shaul, Philip W., Monson, Nancy L, Kounnas, Maria Z, Stüve, Olaf, Herz, Joachim
Publicado no Sci Transl Med (2020)

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism

Por Vetrivel, Kulandaivelu S, Gong, Ping, Bowen, James W, Cheng, Haipeng, Chen, Ying, Carter, Meghan, Nguyen, Phuong D, Placanica, Lisa, Wieland, Felix T, Li, Yue-Ming, Kounnas, Maria Z, Thinakaran, Gopal
Publicado em 2007

Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

Por Kang, David E., Pietrzik, Claus U., Baum, Larry, Chevallier, Nathalie, Merriam, David E., Kounnas, Maria Z., Wagner, Steven L., Troncoso, Juan C., Kawas, Claudia H., Katzman, Robert, Koo, Edward H.
Publicado em 2000

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

Por Cheng, Haipeng, Vetrivel, Kulandaivelu S., Drisdel, Renaldo C., Meckler, Xavier, Gong, Ping, Leem, Jae Yoon, Li, Tong, Carter, Meghan, Chen, Ying, Nguyen, Phuong, Iwatsubo, Takeshi, Tomita, Taisuke, Wong, Philip C., Green, William N., Kounnas, Maria Z., Thinakaran, Gopal
Publicado em 2009

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

Por Kounnas, Maria Z., Danks, Anne M., Cheng, Soan, Tyree, Curtis, Ackerman, Elizabeth, Zhang, Xulun, Ahn, Kwangwook, Nguyen, Phuong, Comer, Dan, Mao, Long, Yu, Chengzhi, Pleynet, David, Digregorio, Paul J., Velicelebi, Gonul, Stauderman, Kenneth A., Comer, William T., Mobley, William C., Li, Yue-Ming, Sisodia, Sangram S., Tanzi, Rudolph E., Wagner, Steven L.
Publicado em 2010