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Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism
BACKGROUND: Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides. Aβ is released from ectodomain cleaved amyloid precursor protein (APP) via intramembranous proteolysis by γ-secretase, a complex consisting of presenilin and a few other proteins. p23/TMP21,...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1803014/ https://ncbi.nlm.nih.gov/pubmed/17288597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-4 |
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