NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

Ectopic cell cycle events (CCEs) mark vulnerable neuronal populations in human Alzheimer disease (AD) and are observed early in disease progression. In transgenic mouse models of AD, CCEs are found before the onset of β-amyloid peptide (Aβ) deposition to form senile plaques, a hallmark of AD. Here,...

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Detalhes bibliográficos
Principais autores: Varvel, Nicholas H., Bhaskar, Kiran, Kounnas, Maria Z., Wagner, Steven L., Yang, Yan, Lamb, Bruce T., Herrup, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786797/
https://ncbi.nlm.nih.gov/pubmed/19907078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39716
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