NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

Ectopic cell cycle events (CCEs) mark vulnerable neuronal populations in human Alzheimer disease (AD) and are observed early in disease progression. In transgenic mouse models of AD, CCEs are found before the onset of β-amyloid peptide (Aβ) deposition to form senile plaques, a hallmark of AD. Here,...

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Bibliographic Details
Main Authors: Varvel, Nicholas H., Bhaskar, Kiran, Kounnas, Maria Z., Wagner, Steven L., Yang, Yan, Lamb, Bruce T., Herrup, Karl
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786797/
https://ncbi.nlm.nih.gov/pubmed/19907078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39716
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