Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

Susceptibility to Alzheimer’s disease (AD) is governed by multiple genetic factors. Remarkably, the LDL receptor–related protein (LRP) and its ligands, apoE and α2M, are all genetically associated with AD. In this study, we provide evidence for the involvement of the LRP pathway in amyloid depositio...

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Detalhes bibliográficos
Main Authors: Kang, David E., Pietrzik, Claus U., Baum, Larry, Chevallier, Nathalie, Merriam, David E., Kounnas, Maria Z., Wagner, Steven L., Troncoso, Juan C., Kawas, Claudia H., Katzman, Robert, Koo, Edward H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC301422/
https://ncbi.nlm.nih.gov/pubmed/11067868
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