Resultados da pesquisa - Longev Healthspan

141

Por Fusco, Salvatore, Maulucci, Giuseppe, Pani, Giovambattista
Publicado em 2012

“...Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively...”
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142

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Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

Por Arlia-Ciommo, Anthony, Piano, Amanda, Svistkova, Veronika, Mohtashami, Sadaf, Titorenko, Vladimir I.
Publicado em 2014

“... beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant...”
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143

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Dietary restriction, mitochondrial function and aging: from yeast to humans

Por Ruetenik, Andrea, Barrientos, Antoni
Publicado no Biochim Biophys Acta (2015)

“... health and increases longevity across organisms. While over the last 15 years extensive research has been...”
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144

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Calorie Restriction in Rodents: Caveats to Consider

Por Ingram, Donald K., de Cabo, Rafael
Publicado no Ageing Res Rev (2017)

“... for investigating mechanisms of aging and longevity. By far, rodent models have been employed most often...”
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145

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Adult Stem Cells and Diseases of Aging

Por Boyette, Lisa B., Tuan, Rocky S.
Publicado em 2014

“... with age. Both progeria, an extreme example of early-onset aging, and heritable longevity have provided...”
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146

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NOVEL ROLES FOR INSULIN RECEPTOR (IR) IN ADIPOCYTES AND SKELETAL MUSCLE CELLS VIA NEW AND UNEXPECTED SUBSTRATES

Por Ramalingam, Latha, Oh, Eunjin, Thurmond, Debbie C.
Publicado em 2012

“.../Longevity. While IR functions in a seemingly pleotropic manner in many cell types, through these three main...”
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147

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Calorie restriction in humans: an update

Por Most, Jasper, Tosti, Valeria, Redman, Leanne M., Fontana, Luigi
Publicado no Ageing Res Rev (2016)

“... nutrition, has been shown to extend healthspan and lifespan in rodent and primate models. Accumulating data...”
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148

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The Effects of Growth Hormone (GH) Treatment on GH and Insulin/IGF-1 Signaling in Long-Lived Ames Dwarf Mice

Por Masternak, Michal M., Panici, Jacob A., Wang, Feiya, Wang, Zhihui, Spong, Adam
Publicado em 2010

“.... This suggests that improving growth of these animals may negatively affect both their healthspan and longevity...”
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149

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Neuronal functions of FOXO/DAF-16

Por Kim, Sun Y., Webb, Ashley E.
Publicado no Nutr Healthy Aging (2017)

“...The FOXO family of transcription factors plays a conserved role in longevity and tissue homeostasis...”
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150

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Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans

Por Boccitto, Marco, Lamitina, Todd, Kalb, Robert G.
Publicado em 2012

“... longevity and healthspan. As aging is the greatest risk factor for developing neurodegenerative diseases...”
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151

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Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Por Levine, Morgan E., Suarez, Jorge A., Brandhorst, Sebastian, Balasubramanian, Priya, Cheng, Chia-Wei, Madia, Federica, Fontana, Luigi, Mirisola, Mario G., Guevara-Aguirre, Jaime, Wan, Junxiang, Passarino, Giuseppe, Kennedy, Brian K., Cohen, Pinchas, Crimmins, Eileen M., Longo, Valter D.
Publicado em 2014

“... followed by moderate protein consumption in old subjects may optimize healthspan and longevity....”
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152

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Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules

Por Kumar, Surinder, Lombard, David B.
Publicado no F1000Res (2016)

“... interventions that can delay the onset of multiple age-related diseases and prolong healthy lifespan (healthspan...”
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153

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Sex Differences in Aging: Genomic Instability

Por Fischer, Kathleen E, Riddle, Nicole C
Publicado no J Gerontol A Biol Sci Med Sci (2018)

“... morbidity particularly late in life. These sex differences in human lifespan and healthspan are consistently...”
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154

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EGF Signaling Comes of Age: Promotion of Healthy Aging in C. elegans

Por Yu, Simon, Driscoll, Monica
Publicado no Exp Gerontol (2010)

“... on healthspan but not lifespan, a gene class that may have been missed in screens focused on longevity endpoint...”
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155

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ELIXIR of LIFE: THWARTING AGING with REGENERATIVE REPROGRAMMING

Por Beyret, Ergin, Redondo, Paloma Martinez, Luengo, Aida Platero, Belmonte, Juan Carlos Izpisua
Publicado no Circ Res (2018)

“... predisposition to degenerative disorders. Therefore, novel interventions that aim to extend the healthspan...”
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156

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Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

Por Schmeisser, Sebastian, Priebe, Steffen, Groth, Marco, Monajembashi, Shamci, Hemmerich, Peter, Guthke, Reinhard, Platzer, Matthias, Ristow, Michael
Publicado em 2013

“... species. DR is widely believed to promote longevity by causing an energy deficit leading to increased...”
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157

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Walking the Oxidative Stress Tightrope: A Perspective from the Naked Mole-Rat, the Longest-Living Rodent

Por Rodriguez, Karl A., Wywial, Ewa, Perez, Viviana I., Lambert, Adrian J., Edrey, Yael H., Lewis, Kaitlyn N., Grimes, Kelly, Lindsey, Merry L., Brand, Martin D., Buffenstein, Rochelle
Publicado em 2011

“... on longevity. Furthermore, comparative data from a wide range of endotherms with disparate longevity remain...”
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158

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Autophagy drives epidermal deterioration in a Drosophila model of tissue aging

Por Scherfer, Christoph, Han, Violet C., Wang, Yan, Anderson, Aimee E., Galko, Michael J.
Publicado em 2013

“... aging in this mutant suggests that in the epidermis healthspan can be uncoupled from longevity. Because...”
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159

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The slow-aging growth hormone receptor/binding protein gene-disrupted (GHR-KO) mouse is protected from aging-resultant neuromusculoskeletal frailty

Por Arum, Oge, Rickman, Dustin J., Kopchick, John J., Bartke, Andrzej
Publicado em 2013

“... research subjects and very rarely studied in animals with extended longevity. In an effort to address...”
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160

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Ayurveda and the science of aging

Por Rao, Rammohan V.
Publicado no J Ayurveda Integr Med (2018)

“..., and extending longevity by stopping or delaying the aging process. By 2030, one in five of the world population...”
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