Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

Dietary restriction (DR) extends lifespan and promotes metabolic health in evolutionary distinct species. DR is widely believed to promote longevity by causing an energy deficit leading to increased mitochondrial respiration. We here show that inhibitors of mitochondrial complex I promote physical a...

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Detaylı Bibliyografya
Asıl Yazarlar: Schmeisser, Sebastian, Priebe, Steffen, Groth, Marco, Monajembashi, Shamci, Hemmerich, Peter, Guthke, Reinhard, Platzer, Matthias, Ristow, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2013
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817383/
https://ncbi.nlm.nih.gov/pubmed/24199155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2013.02.002
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