Impaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal

Impaired Insulin and IGF-1 Signaling (iIIS) in C. elegans daf-2 mutants extends lifespan more than two-fold. Constitutively iIIS increases mitochondrial activity and reduces reactive oxygen species (ROS) levels. By contrast, acute impairment of daf-2 in adult C. elegans reduces glucose uptake and tr...

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Publicado no:Cell Metab
Main Authors: Zarse, Kim, Schmeisser, Sebastian, Groth, Marco, Priebe, Steffen, Beuster, Gregor, Kuhlow, Doreen, Guthke, Reinhard, Platzer, Matthias, Kahn, C. Ronald, Ristow, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844853/
https://ncbi.nlm.nih.gov/pubmed/22482728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.02.013
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