Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ageing in nematodes, zebrafish and mice. We observe the strongest extension of lifespan when...

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Publicado no:Nat Commun
Main Authors: Mansfeld, Johannes, Urban, Nadine, Priebe, Steffen, Groth, Marco, Frahm, Christiane, Hartmann, Nils, Gebauer, Juliane, Ravichandran, Meenakshi, Dommaschk, Anne, Schmeisser, Sebastian, Kuhlow, Doreen, Monajembashi, Shamci, Bremer-Streck, Sibylle, Hemmerich, Peter, Kiehntopf, Michael, Zamboni, Nicola, Englert, Christoph, Guthke, Reinhard, Kaleta, Christoph, Platzer, Matthias, Sühnel, Jürgen, Witte, Otto W., Zarse, Kim, Ristow, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686672/
https://ncbi.nlm.nih.gov/pubmed/26620638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10043
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