Role of Sirtuins in Lifespan Regulation is Linked to Methylation of Nicotinamide

Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. Contrasting recent observations, we here find that overexpression of sir-2.1, the orthologue of mammalian SirT1, does extend C. elegans lifespan. Sirtuins mandatorily convert NAD(+) into nicotinamide (NA...

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Detalhes bibliográficos
Main Authors: Schmeisser, Kathrin, Mansfeld, Johannes, Kuhlow, Doreen, Weimer, Sandra, Priebe, Steffen, Heiland, Ines, Birringer, Marc, Groth, Marco, Segref, Alexandra, Kanfi, Yariv, Price, Nathan L., Schmeisser, Sebastian, Schuster, Stefan, Pfeiffer, Andreas, Guthke, Reinhard, Platzer, Matthias, Hoppe, Thorsten, Cohen, Haim Y., Zarse, Kim, Sinclair, David A., Ristow, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076143/
https://ncbi.nlm.nih.gov/pubmed/24077178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1352
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